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Use of α-methylphenylalanine for studies of brain development in experimental phenylketonuria

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Journal of Inherited Metabolic Disease

Abstract

Experimental phenylketonuria was induced in newborn rats by administration ofl-phenylalanine and α-methylphenylalanine. There was no primary disturbance of myelination, but reduced cell proliferation, early cell death and compensatory hyperplasia were evident in the cerebellum.

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Authors and Affiliations

  1. Max-Planck-Institut für experimentelle Medizin, Forschungsstelle Neurochemie, Hermann-Rein-Str. 3, 3400, Göttingen, FRG

    G. Huether & V. Neuhoff

Authors
  1. G. Huether
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  2. V. Neuhoff
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Huether, G., Neuhoff, V. Use of α-methylphenylalanine for studies of brain development in experimental phenylketonuria. J Inherit Metab Dis 4, 67–68 (1981). https://doi.org/10.1007/BF02263594

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