Marked locomotor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine

  • Maria Carlsson
  • A. Carlsson
Rapid Communication

Summary

The present study demonstrates that the muscarinic antagonist atropine and the α-adrenergic agonist clonidine, though ineffective when administered separately, produced a pronounced locomotor stimulation in monoamine-depleted mice when combined. The atropine + clonidine-induced locomotor stimulation was counteracted by both the α2-adrenoceptor antagonist idazoxan and the acetylcholinesterase inhibitor physostigmine. Thus, it is clear that simultaneous manipulations with cholinergic and adrenergic systems are as effective in restoring locomotion in monoamine-depleted mice as increasing central dopaminergic tone. This finding may have implications for the treatment of a movement disorder like Parkinson's disease.

Keywords

Atropine clonidine locomotion mouse Parkinson's disease 

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References

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Maria Carlsson
    • 1
  • A. Carlsson
    • 1
  1. 1.Department of PharmacologyUniversity of GöteborgGöteborgSweden

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