Summary
Open column, high-performance liquid, and gas-liquid chromatographic procedures have been developed for the purification of synthetic warburganal intermediates (II–V) and drimenin (VI). The usefulness of thinlayer chromatography in revealing an obscured, unwanted product (VI) instead of a desired warburganal intermediate (V) is discussed. The relative stereochemical configuration of IV was confirmed by X-ray analysis.
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Warthen, J.D., Waters, R.M., Flippen-Anderson, J.L. et al. Purification of synthetic warburganal intermediates by open column and high-performance liquid chromatography. Chromatographia 17, 623–626 (1983). https://doi.org/10.1007/BF02261946
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DOI: https://doi.org/10.1007/BF02261946