Application of carbon-11 labelled nicotine in the measurement of human cerebral blood flow and other physiological parameters
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Using positron emission tomography (PET), we measured the regional cerebral blood flow (rCBF) in five normal human subjects after intravenous injection of carbon-11 labelled (R)nicotine. The rCBF of the same subjects was measured by PET using the C15O2 inhalation steady-state method. The distribution of11C activity in the brain after injection of11C-(R)nicotine was almost equivalent to the CBF image obtained with the C15O2 inhalation stead-state method. The kinetics of11C-(R)nicotine in the brain was analysed using a two-compartment model consisting of vascular and brain tissue compartments. The rCBF values obtained with11C-(R)nicotine were higher than with C15O2 gas. The relatively long fixed distribution of11C-(R)nicotine with a short uptake period allows stimulation studies by measurement of CBF to be performed with better photon flux and a longer imaging time than are possible with H215O.
Key wordsCarbon-11 labelled (R)nicotine Cerebral blood flow Positron emission tomography
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