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Chromatographia

, Volume 28, Issue 9–10, pp 513–515 | Cite as

Optical resolution HPLC column packings carrying penicillin sulfoxide nucleus. Part IV. Effect of substituents in the benzyl ester group on the optical resolution efficiency

  • Y. Saotome
  • T. Miyazawa
  • T. Endo
Originals

Summary

Fourteen new vinyl polymers carrying penicillin sulfoxide nucleus, poly (substituted-benzyl 1-oxo-6-metha-crylaminopenicillanate)s, were synthesized in order to investigate the influence of the substituents on the optical resolution capabilities. The resolution efficiency of the high-performance liquid chromatography columns comprising the obtained polymers were examined usingtrans-stilbene oxide and N-acetyl-1-phenethyl-amine. It was found that some columns resolved both racemates, some one, while the others did not separate either. A polymer which has 2,6-dichlorobenzyl moiety was found to resolve both racemates more effectively than the unsubstituted polymer.

Key Words

Column liquid chromatography Optical resolution Polymeric adsorbents Penicillin sulfoxide Substituent effect 

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References

  1. [1]
    Y. Saotome, T. Miyazawa, T. Endo, Chromatographia28, 505 (1989), part III.Google Scholar
  2. [2]
    Y. Saotome, T. Miyazawa, T. Endo, Chromatographia28, 509 (1989), part I.Google Scholar
  3. [3]
    Y. Saotome, T. Miyazawa, T. Endo, Chromatographia,28, 511 (1989), part II.Google Scholar
  4. [4]
    Y. Saotome, T. Miyazawa, T. Endo, J. Polym. Sci. Part C, Polym. Lett.26, 485 (1988).Google Scholar
  5. [5]
    Y. Saotome, T. Miyazawa, T. Endo, unpublished. Correspond with Y.S. for synthetic schemes and spectral data for the monomers and their intermediates.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • Y. Saotome
    • 1
  • T. Miyazawa
    • 1
  • T. Endo
    • 2
  1. 1.Yokohama LaboratoryM. D. Research Co., Ltd., c/o Meiji Seika Kaisha, Ltd.Kohoku-ku, YokohamaJapan
  2. 2.Research Laboratory of Resources UtilizationTokyo Institute of TechnologyMidori-ku, YokohamaJapan

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