, Volume 28, Issue 9–10, pp 437–444 | Cite as

Ion-pair chromatography with divalent counter cations in reversed-phase systems

  • C. Pettersson
  • G. Schill


The chromatographic behaviour of naphthalenedisulfonates when using divalent alkylammonium ions as counter ions in a phosphate buffered mobile phase has been studied. The retention of the disulfonates was found to be based on an ion-exchange process with the adsorbed divalent cation. The retention model is based on studies of the influence of concentration of divalent counter ions, dihydrogen phosphate and sodium, as well as pH, on the retention of mono- and divalent naphthalenesulphonates. No clear indication of specific, multipoint, interactions between the naphthalenedisulfonates and the divalent counter ions was observed.

Key Words

Reversed phase ion-pair chromatography Ion-exchange Divalent cationic counter ions Naphthalenesulfonates Naphthalenedisulfonates 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • C. Pettersson
    • 1
  • G. Schill
    • 1
  1. 1.Department of Analytical Pharmaceutical Chemistry, Biomedical CentreUppsala UniversityUppsalaSweden

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