Advertisement

Rotations induced by L-dopa in parkinsonian rats are reduced by an ingestion of amino acids

  • E. Mizuta
  • S. Kuno
Full Papers

Summary

We studied the effect of amino acid load on L-dopa-induced rotational behavior in rats with unilateral lesion of the nigrostriatal pathway. Pretreatment of rats with an ingestion of high concentration of amino acids significantly reduced the number of rotations induced by subcutaneously injected L-dopa. These results provide the experimental basis for clinical observations that dietary protein affects the response to L-dopa in parkinsonian patients.

Keywords

Amino acid L-dopa Parkinson's disease rat rotation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carter JH, Nutt JG, Woodward WR, Hatcher LF, Trotman TL (1989) Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease. Neurology 39: 552–556PubMedGoogle Scholar
  2. Eriksson T, Granerus A-K, Linde A, Carlsson A (1988) “On-off” phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 38: 1245–1248PubMedGoogle Scholar
  3. Frankel JP, Kempster PA, Bovingdon M, Webster R, Lees AJ, Stern GM (1989) The effects of oral protein on the absorption of intraduodenal levodopa and motor performance. J Neurol Neurosurg Psychiatry 52: 1063–1067PubMedGoogle Scholar
  4. Juncos JL, Fabbrini G, Mouradian MM, Serrati C, Chase TN (1987) Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 44: 1003–1005PubMedGoogle Scholar
  5. König JFR, Klippel RA (1963) The rat brain. Williams and Wilkins, BaltimoreGoogle Scholar
  6. Leenders KL, Poewe WH, Palmer AJ, Brenton DP, Franckowiak RSJ (1986) Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. Ann Neurol 20: 258–262CrossRefPubMedGoogle Scholar
  7. Markovitz DC, Fernstrom JD (1977) Diet and uptake of aldomet by the brain: competition with natural large neutral amino acids. Science 197: 1014–1015PubMedGoogle Scholar
  8. Marsden CD, Parkes JD (1977) Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet i: 345–349CrossRefGoogle Scholar
  9. Mena I, Cotzias GC (1975) Protein intake and treatment of Parkinson's disease with levodopa. N Engl J Med 292: 181–184PubMedGoogle Scholar
  10. Utt JG, Woodward WR, Gancher ST, Merrick D (1987) 3-O-Methyldopa and the response to levodopa in Parkinson's disease. Ann Neurol 21: 584–588CrossRefPubMedGoogle Scholar
  11. Nutt JG, Woodward WR, Hammerstad JP, Carter JH, Anderson JL (1984) The “on-off” phenomenon in Parkinson's disease: relation to levodopa absorption and transport. N Engl J Med 310: 483–488PubMedGoogle Scholar
  12. Pardridge WM (1977) Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J Neurochem 28: 103–108PubMedGoogle Scholar
  13. Pincus JH, Barry K (1987a) Influence of dietary protein on motor fluctuations in Parkinson's disease. Arch Neurol 44: 270–272PubMedGoogle Scholar
  14. Pincus JH, Barry MK (1987b) Plasma levels of amino acids correlate with motor fluctuations in parkinsonism. Arch Neurol 44: 1006–1009PubMedGoogle Scholar
  15. Reches A, Mielke LR, Fahn S (1982) 3-O-Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway. Neurology 32: 887–888PubMedGoogle Scholar
  16. Tsui JK, Ross S, Poulin K, Douglas J, Postnikoff D, Calne S, Woodward W, Calne DB (1989) The effect of dietary protein on the efficacy of L-dopa: a double blind study. Neurology 39: 549–552PubMedGoogle Scholar
  17. Ungerstedt U (1971) Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiol Scand 367 [Suppl]: 69–93PubMedGoogle Scholar
  18. Wade LA, Katzman A (1975) Synthetic amino acids and the nature of L-DOPA transport at the blood-brain barrier. J Neurochem 25: 837–842PubMedGoogle Scholar
  19. Woodward WR, Hammerstad JP, Gliessman P, Nutt JG (1991) Large neutral amino acid inhibition of levodopa transport into monkey CSF. Neurology 41 [Suppl 1]: 289Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • E. Mizuta
    • 1
  • S. Kuno
    • 1
  1. 1.Department of NeurologyUtano National HospitalKyotoJapan

Personalised recommendations