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Editor's note for debate Sporadic dementia of Alzheimer type: Role of amyloid in etiology is challenged

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

Alzheimer's disease is a heterogenous neurodegenerative disorder. Whereas only a minority is due to genetic abnormalities and mostly with early onset, the majority of all Alzheimer cases is sporadic and with late onset. Therefore, in the latter, age-related disturbances in cellular metabolism may come into focus with respect to the etiopathogenesis rather than the primary formation of amyloid. In this “Editor's note for debate”, the role of amyloid as a causative factor of sporadic Alzheimer's disease is challenged. Instead, as a possible primary abnormal event in sporadic Alzheimer's disease, the perturbations in neuronal glucose metabolism and the subsequent ATP deficit with its impacts on the secondary amyloid formation are discussed to open a new field of research and another aspect for debate.

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  1. S. Hoyer

    Present address: Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220-221, D-69120, Heidelberg, Federal Republic of Germany

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    Hoyer, S. Editor's note for debate Sporadic dementia of Alzheimer type: Role of amyloid in etiology is challenged. J Neural Transm Gen Sect 6, 159–165 (1993). https://doi.org/10.1007/BF02260918

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    • DOI: https://doi.org/10.1007/BF02260918

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