Summary
Micellar phase-transfer catalysis (MPTC) offers the opportunity to derivatize carboxylic acids directly in an aqueous matrix without prior extraction of the acids into a suitable aprotic solvent. The currently developed MPTC system consists of a non-ionic surfactant, Arkopal N-130, an ion-pair agent, tetrakis-(decyl)-ammonium bromide, and a novel fluorescence reagent, 9-bromomethylacridine. The MPTC system can be applied to the derivatization of many types of carboxylic acids. The reaction rate is affected by the lipophilicity of the acid and by the presence of other functional groups. For lipophilic carboxylic acids the reaction is complete within 5 min at 60°C and pH 7.0.
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van der Horst, F.A.L., Post, M.H., Holthuis, J.J.M. et al. Derivatization of carboxylic acids with 9-bromomethylacridine using micellar phase-transfer catalysis. Chromatographia 28, 267–273 (1989). https://doi.org/10.1007/BF02260773
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DOI: https://doi.org/10.1007/BF02260773