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Drug metabolism studies using HPLC

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Summary

The analyses of the plasma concentrations of two drugs, one a water soluble weak base and the other a lipophilic ester with acidic metabolites, are used to illustrate the advantages of reversed-phase chromatography over other techniques in drug metabolism studies. The problems associated with each method are discussed and compared.

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Authors and Affiliations

  1. Department of Drug Metabolism, Roche Products Limited, Broadwater Road, Welwyn Garden City, Hertfordshire, UK

    T. R. Marten & R. J. Ruane

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  1. T. R. Marten
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  2. R. J. Ruane
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Marten, T.R., Ruane, R.J. Drug metabolism studies using HPLC. Chromatographia 13, 137–140 (1980). https://doi.org/10.1007/BF02259301

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  • DOI: https://doi.org/10.1007/BF02259301

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