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Very-high-speed liquid column chromatography the system and selected applications

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Instrumentation needed to achieve very high performance (plate/s) liquid chromatography is discussed. With recently available systems using relatively short (100–125 mm) columns of conventional internal diameter (4–6 mm) and packed with 3–5 μm particles, analysis in very short times (usually 1–3 min) is possible. Coupling such columns in series provide very high performance in a time still significantly less than previously encountered. Performance of such liquid chromatographic systems is illustrated with a number of practical examples including analgesic tablets, cosmetics, soft drinks, antioxidants and polyaromatic hydrocarbons.

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Authors and Affiliations

  1. Chromatography Division, The Perkin-Elmer Corporation, 06856, Norwalk, CT, USA

    J. L. DiCesare, M. W. Dong & L. S. Ettre

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  1. J. L. DiCesare
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  2. M. W. Dong
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  3. L. S. Ettre
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Additional information

Enlarged text of a paper presented at the 32nd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, March 9–13, 1981, Atlantic City, New Jersey (Paper No. 462).

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DiCesare, J.L., Dong, M.W. & Ettre, L.S. Very-high-speed liquid column chromatography the system and selected applications. Chromatographia 14, 257–268 (1981). https://doi.org/10.1007/BF02259263

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