Experimental Brain Research

, Volume 88, Issue 1, pp 224–228 | Cite as

On the use of isofluorane as an anaesthetic for visual neurophysiology

  • D. A. Tigwell
  • J. Sauter
Research Note

Summary

The use of the anaesthetic isofluorane (ForeneR, Deutsche Abbott) for unit cell recordings from the monkey striate cortex is considered. Two aspects are emphasised; the maintenance of sustained components of response and the stability of vegetative physiology under isofluorane anaesthesia. A comparison of the use of isofluorane with halothane is made. The similar physical constants of isofluorane and halothane allow the easy adaptation of conventional delivery systems to use with isofluorane, when allowance is made for differences in anaesthetic strength.

Key words

Isofluorane Anaesthesia Visual neurophysiology Striate cortex Sustained responses 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Atlee JL III, Alexander SC (1977) Halothane effects on conductivity of the AV node and His-Purkinje system in the dog. Anesth analg (Cleve) 56:378–386Google Scholar
  2. Byles PH, Dobkin AB, Ferguson JH (1971a) Forane (Compound 469)2: Biochemical effects of repeated administration to animals, response to bleeding and compatability with epinephrine. Can Anaesth Soc J 18:387–396PubMedGoogle Scholar
  3. Byles PH, Dobkin AB, Jones DB (1971b) Forane (Compound 469) 3: Comparative effects of prolonged anaesthesia on mature beagle dogs and young rhesus monkeys. Can Anaesth Soc J 18:397–407PubMedGoogle Scholar
  4. Christ DD, Satoh H, Kenna JG, Pohl LR (1988) Potential metabolic basis for enfluorane hepatitis and the apparent cross-sensitization between enfluorane and halothane. Drug Metab Dispos 16:135–140PubMedGoogle Scholar
  5. Cromwell TH, Eger EI (1971) Forane uptake, excretion, and blood solubility in man. Anaesthesiology 35:401–408Google Scholar
  6. Demoor A VON (1971) Ist Halothan eine inerte Substanz? Übersicht und eigene Untersuchungen. Berl Münch Tierartzl Wochenschr 100:181–187Google Scholar
  7. Dobkin AB, Byles PH, Ghanoon S, Valbuena DA (1971) Clinical and laboratory evaluation of a new inhalation anaesthetic: Forane (Compound 469) CHF2-O-CHCLF3 (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). Can Anaesth J 18:264–271Google Scholar
  8. Dobkin AB, Kim D, Choi JK (1973) Blood serum fluoride levels with enfluorane (Ethrane) and Isofluorane (Forane) anaesthesia during and following major abdominal surgery. Can Anaesth J 20:494–498Google Scholar
  9. Eger EI (1981a) Isofluorane: a review. Anaesthesiology 55:559–576Google Scholar
  10. Eger EI (1981b) Isofluorane (Forane): a compendium and reference. Ohio Medical Products, Madison WisconsinGoogle Scholar
  11. Eger EI, Smith NT, Stoelting RK (1970) Cardiovascular effects of halothane in man. Anesthesiology 32:396–409PubMedGoogle Scholar
  12. Gilbert M, Roberts SL, Mori M, Blomberg R, Tinker JH (1988) Comparative coronary vascular reactivity and hemodynamics during halothane and isofluorane anaesthesia in swine. Anesthesiology 68:243–253PubMedGoogle Scholar
  13. Graves CL, McDermott RW, Bidwai A (1974) Cardiovascular effects of isofluorane in surgical patients. Anesthesiology 41:486–489PubMedGoogle Scholar
  14. Hammond P (1978) Inadequacy of nitrous oxide/oxygen mixtures for maintaining anaesthesia in cats: satisfactory alternatives. Pain 5:143–151PubMedGoogle Scholar
  15. Harper MH, Johnson BH, Collins P (1980) Hepatic injury following halothane, enfluorane and isofluorane anaesthesia in rats. Anesthesiology 53:S242Google Scholar
  16. Harper MH, Collins P, Johnson B (1981) Decrease in hepatic blood flow may cause injury during halothane anesthesia. Anesth Analg (Cleve) 60:253–254Google Scholar
  17. Ikeda H, Wright MJ (1974) Sensitivity of neurones in visual cortex (Area 17) under different levels of anaesthesia. Exp Brain Res 20:471–484CrossRefPubMedGoogle Scholar
  18. Holaday Da, Fiserva-Bergerova V, Latto IP (1975) Resistance of isofluorane to biotransformation in Man. Anaesthesiology 43:325–332Google Scholar
  19. Horn J, Konchigeri HN, Eckenhof JE (1972) A new anaesthetic agent Forane; preliminary observations in Man. Anesth Analg (Cleve) 51:439–477Google Scholar
  20. Lee BB, Valberg A, Tigwell DA, Tryti J (1987) An account of responses of spectrally opponent neurones in macaque lateral geniculate nucleus to successive contrast. Proc R Sco (Lond) B 230:293–314Google Scholar
  21. Levy W (1982) Cardiac arrhythmias. Can Anaesth Soc J 29:SupplS28-S34Google Scholar
  22. Linde HW, Oh SO, Homi J (1975) Cardiovascular effects of isofluorane in surgical patients. Anaesthesiology 41:486–489Google Scholar
  23. Lynch C (1988) Effects of halothane and isofluorane on the isolated human ventricular myocardium. Anesthesiology 68:429–432PubMedGoogle Scholar
  24. Mallow JE, White RD, Cucchiara RF (1976) Hemodynamic effects of isofluorane and halothane in patients with coronary artery disease. Anesth Analg (Cleve) 55:135–138Google Scholar
  25. Miller RD, Eger EI, Way WL (1971a) Comparative neuromuscular effects of Forane and halothane alone and in combination with d-tubocurarine in man. Anesthesiology 35:38–42PubMedGoogle Scholar
  26. Miller RD, Way WL, Dolan WM, Stevens WC, Eger EI (1971b) Comparative neuromuscular effects of pancuronium, gallamine and succinylcholine during Forane and halothane anaesthesia in man. Anesthesiology 35:509–514PubMedGoogle Scholar
  27. Pauca AL, Dripps RD (1973) Clinical experience with isofluorane (Forane). Br J Anaesth 45:697–703PubMedGoogle Scholar
  28. Raj PP, Tod MJ, Jenkins MT (1967) Halothane biotransformation in Man: a quantitative study. Anaesthesiology 28:711–715Google Scholar
  29. Reyder K, Forbes J, Alter H (1967) Halothane biotransformation in Man: a quantitative study. Anesthesiology 28:711–715PubMedGoogle Scholar
  30. Richards CD, Webb AC (1975) The effect of nitrous oxide on cats anaesthetized with Brietal. J Physiol (Lond) 245:72–73PGoogle Scholar
  31. Russell WJ (1973) Nitrous oxide — is it an adequate anaesthetic? J Physiol (Lond) 231:20–21PGoogle Scholar
  32. Saidman LJ, Eger EI (1964) Effect of nitrous oxide and of narcotic premedication on the alveolar concentration of halothane required for anaesthesia. Anesthesiology 25:302–306PubMedGoogle Scholar
  33. Steffey EP (1980) Isoflurane concentration delivered by isofluorane and halothane-specific vapourizers. Anesthesiology 53:S19Google Scholar
  34. Steffey EP, Zinkel J, Howland D (1979) Minimal changes in blood cell counts and biochemical values associted with prolonged isofluorane anaesthesia of horses. Am J Vet Res 40:1646–1648PubMedGoogle Scholar
  35. Stevens WC, Cromwell TH, Halsey MJ (1971) Cardiovascular effects of a new inhalation anaesthetic, Forane, in human volunteers at constant arterial carbon dioxide tension. Anaesthesiology 35:8–16Google Scholar
  36. Stevens WC, Dolan WM, Gibbons RT, White A, Eger EI, Miller RD, de Jong RH, Elashoff RM (1975) Minimum alveolar concentrations (MAC) of isofluorane with and witout nitrous oxide in patients of various ages. Anesthesiology 42:197–200PubMedGoogle Scholar
  37. Stevens WC, Eger EI, White A (1975) Comparative toxicities of halothane, isofluorane and diethyl ether at sub-anaesthetic concentrations in laboratory animals. Anesthesiology 42:408–419PubMedGoogle Scholar
  38. Stevens WC, Eger EI, White A (1977) Comparative toxicities of enfluorane, fluroxene and nitrous oxide at sub-anaesthetic concentrations in laboratory animals. Can Anaesth Soc 24:479–490Google Scholar
  39. Suzuko H, Azuma M (1976) A glass-insulated “Elgiloy” microelectrode for recording unit activity in chronic monkey experiments. Electroenceph Clin Neurophysiol 41:93–95CrossRefPubMedGoogle Scholar
  40. Venes JL, Collins WF, Taub A (1971) Nitrous oxide, an anaesthetic for experiments in cats. Am J Physiol 220:2028–2031PubMedGoogle Scholar
  41. Wolfson B, Hetrick WD, Lake CL (1978) Anaesthetic indices — further data. Anaesthesiology 48:187–190Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • D. A. Tigwell
    • 1
  • J. Sauter
    • 1
  1. 1.Department of NeurobiologyMax-Planck Institute for Biophysical ChemistryGöttingenFederal Republic of Germany

Personalised recommendations