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Importance of intra-therapy single-photon emission tomographic imaging in calculating tumour dosimetry for a lymphoma patient

European Journal of Nuclear Medicine volume 18, pages 432–435 (1991)Cite this article

Abstract

The dosimetry for two, similarly sized tumours in a lymphoma patient being treated with non-bone marrow ablative, monoclonal antibody therapy is reported. The 45-year-old man was infused with 2.48 GBq (67 mCi) of131I-labelled MB-1. Prior to therapy, a time series of diagnostic conjugate-view images and a radionuclide transmission scan were obtained and processed to obtain time-activity curves. Starting 2 days after the therapeutic infusion of radioactivity, a second conjugate-view time series was obtained. At that time, a quantitative single-photon emission tomography (SPET) acquisition was also carried out. Pre- and post-therapy X-ray computed tomography scans demonstrated a percentage reduction in volume for the right tumour which was 3.8 times that for the left tumour. In contrast, diagnostic conjugate views by themselves estimated the absorbed dose to be the same for the two tumours. Addition of therapy conjugate-view data increased the right-over-left ratio but only to 1.22. Normalizing either time-activity series by the intra-therapy SPET results increased the ratio to greater than 1.5. We assume here that a differential dose is correct according to the differential tumour shirnkage. One can further assume that the largest ratio corresponds most certainly to the most accurate dosimetric method. Other assumptions are possible. While additional study is essential, data from this patient suggest that the preferred dosimetric method is intra-therapy SPET normalization of either time series.

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Author notes

  1. Kenneth F. Koral

    Present address: Department of Internal Medicine, Nuclear Medicine Division, B16412 0028, 48109, Ann Arbor, MI, USA

  2. Fayez M. Swailem

    Present address: V.A. Medical Center, 85723, Tucson, AZ, USA

Affiliations

  1. Department of Internal Medicine, Nuclear Medicine Division, B16412 0028, 48109, Ann Arbor, MI, USA

    Kenneth R. Zasadny, Fayez M. Swailem, Steven F. Buchbinder, Mark S. Kaminski & Richard L. Wahl

  2. Department of Radiology, University of Michigan, B16412 0028, 48109, Ann Arbor, MI, USA

    Isaac R. Francis

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  1. Kenneth F. Koral
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  2. Kenneth R. Zasadny
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  3. Fayez M. Swailem
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  4. Steven F. Buchbinder
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  5. Isaac R. Francis
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  6. Mark S. Kaminski
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  7. Richard L. Wahl
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Koral, K.F., Zasadny, K.R., Swailem, F.M. et al. Importance of intra-therapy single-photon emission tomographic imaging in calculating tumour dosimetry for a lymphoma patient. Eur J Nucl Med 18, 432–435 (1991). https://doi.org/10.1007/BF02258433

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  • DOI: https://doi.org/10.1007/BF02258433

Key words

  • Tumour dosimetry
  • Single-photon emission tomography (SPET) quantification
  • Lymphoma
  • Monoclonal antibody
  • Radionuclide therapy