Journal of Biomedical Science

, Volume 3, Issue 6, pp 454–460 | Cite as

Exercise training increases acetylcholine-stimulated endothelium-derived nitric oxide release in spontaneously hypertensive rats

  • Hsiun-ing Chen
  • I-Ping Chiang
  • Chauying J. Jen
Original Paper


This study investigated the effects of exercise training on the regional release of endothelium-derived nitric oxide (EDNO) in spontaneously hypertensive rats (SHR). Male SHR and Wistar-Kyoto rats were divided into control and training groups, respectively. The training groups received moderate exercise by running on a drum exerciser for 60 min/day, 5 days/week for 10 weeks. At the end of experiments, thoracic aortae and common carotid arteries were excised. Acetylcholine (ACh)-induced relaxing responses due to EDNO release were evaluated in the presence of indomethacin. Vascular relaxing responses to A23187 or to sodium nitroprusside (SNP) were also studied. Our results indicated that after training, (1) the vascular sensitivity of thoracic aortae to ACh-induced relaxation was elevated when indomethacin was present; this effect was absent in the common carotid artery and it was abolished by adding Nω-nitro-L-arginine, and (2) no significant changes in SNP- or A23187-induced vascular relaxing responses, both being nonreceptor-mediated processes, were observed. We can conclude that for both hypertensive and normotensive rats, exercise training may increase receptor-mediated agonist-stimulated EDNO release in the thoracic aorta, but not in the common carotid artery.

Key Words

Acetylcholine Sodium nitroprusside Receptor-mediated processes Hypertension 


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Copyright information

© National Science Council 1996

Authors and Affiliations

  • Hsiun-ing Chen
    • 1
  • I-Ping Chiang
    • 1
  • Chauying J. Jen
    • 1
  1. 1.Department of PhysiologyNCKU Medical CollegeTainanTaiwan 701 (ROC)

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