Journal of Biomedical Science

, Volume 1, Issue 2, pp 100–104 | Cite as

Cytogenetic study of mentally retarded children in Taipei

  • Sheng Wang-Wuu
  • Yu-Ming Lai
  • Wuh-Liang Hwu
  • Tso-Ren Wang
  • Kuang-Dong Wuu
Original Paper


560 blood samples collected from mentally retarded children in Taipei were karyotypically analyzed for the incidence of fragile X and other chromosome abnormalities. The fragile site at Xq27.3 was observed in 18 patients (3.21%), 11 males and 7 females, out of the 560 blood cultures using M medium. Down syndrome (6.25%), 24 males and 11 females, was the other major category of abnormality. Other abnormalities, including inversion, translocation, deletion, duplication, ring as well as an extra marker chromosome were observed. The overall incidence of chromosomal abnormalities in these children was 14.82%.

Key Words

Fragile X Chromosome abnormalities Mental retardation 


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Copyright information

© National Science Council 1994

Authors and Affiliations

  • Sheng Wang-Wuu
    • 2
  • Yu-Ming Lai
    • 2
  • Wuh-Liang Hwu
    • 1
  • Tso-Ren Wang
    • 1
  • Kuang-Dong Wuu
    • 2
  1. 1.Department of PediatricsNational Taiwan University HospitalTaipeiTaiwan, Republic of China
  2. 2.Institute of GeneticsNational Yang Ming Medical CollegeTaipeiTaiwan (Republic of China)

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