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Reduced luteinizing hormone secretion in women with Parkinson's disease

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

Plasma luteinizing hormone (LH) levels were significantly lower in 10 postmenopausal women with Parkinson's disease (PD) compared to agematched controls. The remaining hypophyseal hormones and gonadal steroids were similar in PD patients and in controls, suggesting a selective alteration of hypothalamic dopaminergic mechanisms which regulate LH secretion.

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References

  • Barraclough DA, Wise PM (1982) The role of cathecolamines in the regulation of pituitary luteinizing hormone and follicle-stimulating hormone secretion. Endocr Rev 3: 91–119

    Google Scholar 

  • Brown E, Brown GH, Kofman O, Quarrington B (1978) Sexual function and affect in parkinsonian men treated with L-Dopa. Am J Psychiatry 135: 1552–1555

    Google Scholar 

  • Conte-Devolx B, Pfister B, Rey M, Conte-Devolx J, (1987) La function endocrine ante-hypophysaire dans la maladie de Parkinson. Presse Med 12: 566–568

    Google Scholar 

  • Den Hartog WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralisis agitans. J Neurol Neurosurg Psychiatry 23: 283–290

    Google Scholar 

  • Fahn S, Elton RL, Agid Y, Barbeau A, Calne DB, Duvoisin RC, Hoehn MM, Jankovic J, Klawans HL, Lang AE, Lataste X, Liebermann AN, Marsden CD, Markham CH, Mayeux R, Rinne UK, Stern GM, Teychenne P, Yahr MD (1987) Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson's disease, vol 2. Mcmillan Healthcare Information, New York, pp 153–163

    Google Scholar 

  • Fioretti P, Cagnacci A, Paoletti AM, Gambacciani M, Soldani R, Mauro GA, Melis GB (1989) Effects of the antidopaminergic drug veralipride on LH and PRL secretion in postmenopausal women. J Endocrinol Invest 12: 295–301

    Google Scholar 

  • Forno LS, Norville RL (1981) Synaptic morphology in the human locus coeruleus. Acta Neuropathol 53: 524–531

    Google Scholar 

  • Gambacciani M, Melis GB, Paoletti AM, Cagnacci A, Mais V, Petacchi FD, Fioretti P (1987) Pulsatile luteinizing hormone relase in postmenopausal women: effect of chronic bromocriptine administration. J Clin Endocrinol Metab 65: 465–467

    Google Scholar 

  • Gross KM, Matsumoto AM, Bremner WJ (1987) Differential control of luteinizing hormone and follicle-stimulating hormone secretion by luteinizing hormone-releasing hormone pulse frequency in man. J Clin Endocrinol Metab 64: 675–680

    Google Scholar 

  • Hall JE, Brodie TD, Badger TM, Rivier J, Vale W, Conn PM, Shoenfeld D, Crowley WF (1988) Evidence of differential control of FSH and LH secretion by gonadotropinreleasing hormone (Gn RH) from the use of a Gn RH antagonist J Clin Endocrinol Metab 7: 524–531

    Google Scholar 

  • Hornykiewicz C, Kish SJ (1986) Biochemical pathophysiology of Parkinson's disease. Adv Neurol 45: 19–34

    Google Scholar 

  • Hyyppa MT, Langvik VA, Rinne UK (1978) Plasma pituitary hormones, in patients with Parkinson's disease treated with bromocriptine. J Neural Transm 42: 151–157

    Google Scholar 

  • Javoy-Agid F, Ruberg M, Pique L, Bertagna X, Taquet H, Studler JM, Cesselin F, Epelbaum J, Agid Y (1984) Biochemistry of hypothalamus in Parkinson's disease. Neurology 34: 672–675

    Google Scholar 

  • Kirkpatrick B, Tamminga CA (1988) The endocrinology of extrapyramidal disorders. Neurol Clin 6: 159–172

    Google Scholar 

  • Lachelin GCL, Leblanc H, Yen SSC (1977) The inhibitory effect of dopamine-agonists on LH release in women. J Clin Endocrinol Metab 44: 728–732

    Google Scholar 

  • Langston JW, Forno LS (1978) The hypothalamus in, Parkinson's disease. Ann Neurol 3: 129–133

    Google Scholar 

  • Leblanc H, Lachelin GCL, Abu-Fadil S, Yen SSC (1976) Effect of dopamine infusion on pituitary hormone secretion in humans. J Clin Endocrinol Metab 43: 668–674

    Google Scholar 

  • Ling N, Ying SY, Ueno N, Shimasaki S, Esh F, Hotta M, Guillemin R (1986) Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321: 779–782

    Google Scholar 

  • Lundberg PO (1972) Blood levels of FSH, LH, TSH and GH in parkinsonian patients before and during L-Dopa treatment. Acta Neurol Scand 48: 427–432

    Google Scholar 

  • Melis GB, Paoletti AM Mais V, Gambacciani M, Guarnieri G, Strigini F, Fruzzetti F, Fioretti P (1981) Inhibitory effect of the dopamine agonist bromocriptine on the postcastration gonadatropin rise in women. J Clin Endocrinol Metab 53: 530–535

    Google Scholar 

  • Martin JB, Reichlin S (1987) Neuropharmacology of anterior pituitary, regulation. In: Martin JB, Reichlin S (eds) Clinical neuroendocrinology. FA Davis, Philadelphia, p 45

    Google Scholar 

  • Nappi G, Petraglia F, Martignoni E, Facchinetti F, Bono G, Genazzani AR (1985) β-Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients. Neurology 35: 1371–1374

    Google Scholar 

  • Rasmussen DD, Liu JH, Wolf PK, Jen SSC (1986) Gonadotropin-releasing hormone neurosecretion in the human hypothalamus. In vitro regulation by dopamine. J Clin Endocrinol Metab 62: 479–483

    Google Scholar 

  • Reid RL, Quigley ME, Yen SSC (1983) The disappearacne of opioidergic regulation of gonadotropin secretion in postmenopausal women. J Clin Endocrinol Metab 57: 1107–1110

    Google Scholar 

  • Rinne UK (1979) Neuroendocrine and extrapyramidal dopamine neurons in Parkinson's disease. In: Muller EE, Agnoli A (eds) Neuroendocrine correlates in neurology and psychiatry. Elsevier, Amsterdam, pp 119–125

    Google Scholar 

  • Rivier C, Rivier J, Vale W (1986) Inhibin-mediated feedback control of follicle-stimulating hormone secretion in the female rate. Science 234: 205–208

    Google Scholar 

  • Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J (1986) Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321: 776–779

    Google Scholar 

  • Veldhuis JD, Evans WS, Rogol AD, Thorner MO, Drake CR, Merriam GR, Johnson ML (1984) Intensified rates of venous sampling unmask the presence of spontaneous high frequency pulsations of luteinizing hormone in man. J Clin Endocrinol Metab 59: 96–102

    Google Scholar 

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Bonuccelli, U., Piccini, P., Napolitano, A. et al. Reduced luteinizing hormone secretion in women with Parkinson's disease. J Neural Transm Gen Sect 2, 225–231 (1990). https://doi.org/10.1007/BF02257653

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  • DOI: https://doi.org/10.1007/BF02257653

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