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Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography

  • Short Communication
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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.

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Author notes

  1. A. Nordberg

    Present address: Department of Pharmacology, University of Uppsala, Box 591, S-751 24, Uppsala, Sweden

Authors and Affiliations

  1. Department of Organic Chemistry, University of Uppsala, Box 591, S-751 24, Uppsala, Sweden

    Y. Andersson, J. Ulin & B. Långström

  2. Department of Diagnostic Radiology, University of Uppsala, Box 591, S-751 24, Uppsala, Sweden

    A. Lilja

  3. Department of The Svedberg Laboratory, University of Uppsala, Box 591, S-751 24, Uppsala, Sweden

    H. Lundqvist

  4. Hospital Pharmacy, University Hospital, Box 591, S-751 24, Uppsala, Sweden

    P. Hartvig

  5. Department of Geriatric Medicine, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden

    A. Nordberg, M. Viitanen, K. Amberla & B. Winblad

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  1. A. Nordberg
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Nordberg, A., Hartvig, P., Lilja, A. et al. Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J Neural Transm Gen Sect 2, 215–224 (1990). https://doi.org/10.1007/BF02257652

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  • DOI: https://doi.org/10.1007/BF02257652

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