Abstract
In 50 healthy subjects (23 female, 27 male, aged 18–81) and 24 patients with Alzheimer's disease (AD) (11 female, 13 male, aged 58–88) DHEAS and CRT plasma levels were studied. In normal subjects there was a clear negative correlation of DHEAS to age, while no significant age correlated decrease of CRT plasma levels was found. There was a significant decrease in the DHEAS/CRT ratio in elderly controls (aged>60) as compared to young individuals (aged<45). Overall there was a trend to lower DHEAS/CRT ratios in AD patients compared to age matched controls out of the total group of normals (P<0.1), there was a significant decrease of this ratio in female AD patients (P<0.05), compared to age matched female controls, but there was none in male Alzheimers; furthermore there was a significant difference in CRT plasma levels between female AD patients and age matched female controls (P<0.01) and between female and male AD patients (P<0.05). Considering the antiglucocorticoid effects of DHEAS, this ratio may account for its protective effect against hippocampal degeneration caused by glucocorticoids and possibly for the higher rate of AD in females.
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References
Carpenter WT, Gruen PH (1982) Cortisol's effect on human mental functioning. J Clin Psychopharmacol 2:91–101
Cuckle H, Stone R, Smith D, Wald N, Brammer M, Hajmohammedreza I, Levy R, Chard T, Perry L (1990) Dehydroepiandrosterone sulfate in Alzheimer's disease. Lancet ii:449–450
Davis KL, Davis KM, Greenwald BS, Mohs RC, Mathe AA, Johns CA, Horvath TB (1986) Cortisol and Alzheimer's disease, I: Basal studies. Am J Psychiatry 143:300–305
Dodt C, Dittmann J, Hruby J, Späth-Schwalbe E, Born J, Schüttler R, Fehm HL (1991) Different regulation of adrenocorticotropin and cortisol secretion in young, mentally healthy elderly and patients with senile dementia of Alzheimer's type. J Clin Endocrinol Metab 72:272–276
Flood JF, Smith GE, Roberts E (1988) Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 447:267–278
Greenwald BS, Mathe AA, Mohs RC, Levy MI, Johns CA, Davis KL (1986) Cortisol and Alzheimer's disease, II: dexamethasone suppression, dementia severity and affective symptoms. Am J Psychiatry 143:442–446
Gurevich D, Siegel B, Dumlao M, Perl E, Chaitin P, Bagne C, Oxenkrug G (1990) HPA axis responsitivity to dexamethasone and cognitive impairment in dementia. Prog Neuropsychopharmacol Biol Psychiatry 14:297–308
Hermann C, Stern RG, Losonzcy MF, Jaff S, Davidson M (1991) Diagnostic and pharmacological approaches in Alzheimer's disease. Drugs Aging 1:144–162
Kay DWK (1986) The descriptive epidemiology of the dementias. In: Neurology, Proceedings of the XIIIth World Congress of Neurology, Hamburg, Sept 1–6, 1985, pp 26–33
Lawlor BA, Tsuboyama G, Ryan T, Mohs RC, Davis BM, Davidson M, Gabriel S, Davis KL (1992) Agitation and postdexamethasone cortisol levels in Alzheimer's disease. Am J Psychiatry 149:546–548
Leblhuber F, Windhager E, Reisecker F, Steinparz FX, Dienstl E (1990) Dehydroepiandrosterone sulfate in Alzheimer's disease. Lancet ii:449
Leblhuber F, Windhager E, Steinparz FX, Dienstl E, Reisecker F, Rittmannsberger H (1991a) Dehydroepiandrosterone-sulfate (DHEAS) serum levels in normal aging and Alzheimer's disease (AD). Age 14:116–118
Leblhuber F, Windhager E, Weber J, Steinparz FX, Reisecker F, Dienstl E (1991b) Antiglucocorticoid effects of dehydroepiandrosteronesulfate (DHEAS): serum levels of cortisol and DHEAS in normal controls. Age 14:138
Lucey JV, O'Keane V, O'Flinn K, Clare AW, Dinan TG (1991) Gender and age differences in the growth hormone response to pyridostigmine. Int J Clin Psychopharmacol 6:105–109
McIntosh MK, Berdanier CD (1988) Differential effects of adrenalectomy and starvation refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats. J Nutr 118:1011–1017
Mohan PF (1989) Dehydroepiandrosterone and Alzheimer's disease. Lancet ii:1048–1049
Mölsä PK, Marttila RJ, Rinne UK (1982) Epidemiology of dementia in a Finnish population. Acta Neurol Scand 65:541–552
Näsman B, Ollson T, Bäckström T, Erikson S, Grankvist K, Viitanen M, Bucht G (1991) Serum dehydroepiandrosterone sulfate in Alzheimer's disease and multiinfarct dementia. Biol Psychiatry 30:684–690
Orentreich N, Brind JL, Rizer RL, Vogelman JH (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59:551–555
Sapolsky RM, Krey LC, McEwen BS (1986) The neuroendocrinology of stress and aging; the glucocorticoid cascade hypothesis. Endocrinol Rev 7:284–301
Schneider LS, Hinsey M, Lyness S (1992) Plasma dehydroepiandrosterone sulfate in Alzheimer's disease. Biol Psychiatry 31:205–208
Späth-Schwalbe E, Dodt C, Dittmann J, Schuettler R, Fehm HL (1990) Dehydroepiandrosterone sulfate in Alzheimer's disease. Lancet i:1412
Sunderland T, Merril CR, Harrington MG, Lawlor BA, Molchan SE, Martinez R, Murphy DL (1989) Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet ii:570
Svec F, Lopez-S A (1989) Antiglucocorticoid actions of dehydroepiandrosterone and low concentrations in Alzheimer's disease. Lancet ii:1335–1336
Touitou Y, Sulon J, Bogdan A, Touitou C, Reinberg A, Beck H, Sodoyez JC, Demey-Ponsart E, Cauwenberge HV (1982) Adrenal circadian system in young and elderly human subjects: a comparative study. J Endocrinol 93:201–210
Touitou Y, Carayon A, Reinberg A, Bogdan A, Beck H (1983) Differences in the seasonal rhythmicity of plasma prolactin in elderly human subjects: detection in woman but not in men. J Endocrinol 96:65–71
Wolkowitz OM, Reus VI, Weingartner H, Thomsen K, Breier A, Doran A, Rubinow D, Pickar D (1990) Cognitive effects of corticoids. Am J Psychiatry 147:1297–1300
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Leblhuber, F., Neubauer, C., Peichl, M. et al. Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD). Psychopharmacology 111, 23–26 (1993). https://doi.org/10.1007/BF02257402
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DOI: https://doi.org/10.1007/BF02257402