Summary
A high performance liquid chromatographic system has been developed for the resolution of ten anti-inflammatory drugs. Isocratic separation was achieved using a Spherisorb 5μm ODS column with an eluent consisting of water-orthophosphoric acid to pH 3.2: acetonitrile: methanol (52∶35∶13). A comparison was made between chloroform/acetonitrile (3∶2) and hexane/ether (1∶1) as solvents for the extraction of these drugs from serum.
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Omile, C.I., Tebbett, I.R. & Danesh, B. Determination of ten anti-inflammatory drugs in serum by isocratic liquid chromatography. Chromatographia 22, 187–188 (1986). https://doi.org/10.1007/BF02257324
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DOI: https://doi.org/10.1007/BF02257324