Summary
The reverse-phase, high-pressure liquid chromatographic capacity factors (k') of a series of 18 betablocking agents were determined in order to establish correlations with their distribution coefficient values (D), obtained from four bibliographic sources. Under the three pH conditions studied (3.5, 6.2 and 7.5) statistically significant linear correlations (p< 0.002) between log k' and log D values were obtained for the four series studied. In this series it is concluded that the k' factor is a useful and reliable relative lipophilicity parameter.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. M. Pla Delfina, J. Moreno, J. Pharmacokin. Biopharm.9, 191 (1981).
P. J. Taylor, J. M. Cruickshank, J. Pharm. Pharmacol.36, 118 (1984).
P. B. Woods, M. L. Robinson, J. Pharm. Pharmacol.33, 172 (1981).
R. D. Schoenwald, H. Huang, J. Pharm. Sci.72, 1266 (1983).
P. H. Hinderling, O. Schmidlin, J. K. Seydel, J. Pharmacokin. Biopharm.12, 263 (1984).
L. Lacko, B. Wittke, Arzneim. Forsch./Drug Res.35, (1), 961 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vilá, J.I., Obach, R., Prieto, R. et al. Liquid chromatographic capacity factor as an indicator of lipophilicity in a series of betablocker drugs. Chromatographia 22, 48–50 (1986). https://doi.org/10.1007/BF02257296
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02257296