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Chemistry of Heterocyclic Compounds

, Volume 36, Issue 8, pp 905–910 | Cite as

Synthesis of spiro[isoquinoline-4,4′-pyran]-3-imines

  • V. M. Kisel'
  • M. O. Platonov
  • E. O. Kostyrko
  • V. R. Kovtunenko
Article

Abstract

A method has been developed for the synthesis of 4-[2-(bromomethyl)phenyl] tetrahydro-2H-4-pyrancarbonitrile and a study was carried out on the reaction of this compound with primary amines, which, depending on the conditions, leads to either 4-[2-(R-aminomethyl)phenyl]tetrahydro-2H-4-pyrancarbonitriles or hydrobromides of 2-R-aryl-2,3,2′,3′,5′,6′-hexahydrospiro[isoquinoline-4(1H),4′-pyran]-3-imines.

Keywords

heterocyclic spirans spirocyclic isoquinolines spiro[isoquinolinepyrans] 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • V. M. Kisel'
  • M. O. Platonov
  • E. O. Kostyrko
  • V. R. Kovtunenko

There are no affiliations available

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