Chemistry of Heterocyclic Compounds

, Volume 36, Issue 1, pp 74–76 | Cite as

Products of the reaction of 2-chloro-6-thio-7-methyl-purine with amines

  • P. M. Kochergin
  • E. V. Aleksandrova
  • V. S. Korsunskii


Treatment of 2-chloro-6-thio-7-methylpurine with aniline, piperidine, or morpholine with heating in DMF gives 2-phenylamino(piperidino or morpholino)-6-thio-7-methylpurine. The scheme for the formation of the side products 2,6-dithio-and 2,6-dipiperidino-7-methylpurine is discussed.


chloropurine thiopurines chlorothiopurines aminopurines aniline morpholine piperidine 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • P. M. Kochergin
    • 1
  • E. V. Aleksandrova
    • 2
  • V. S. Korsunskii
    • 1
  1. 1.Center for the Chemistry of Medicnal CompoundsAll Russian Chemico-Pharmaceutical Science Research InstituteMoscow
  2. 2.Zaporozh'ye State Medicinal UniversityZaporozh'yeUkraine

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