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Studies on monobactams II. Synthesis and β-lactamase inhibitory activity of 4α-methyl-3-[(thien-2-yl)-methylene]-2-azetidinone-1-sulfonate

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Two monobactam derivatives, potassium 4α-methyl-(3E)-[(thien-2-yl)methylene]-2-azetidinone-1-sulfonate and its (3Z)-isomer, were prepared and evaluated for their β-lactamase inhibitory activities. These compounds were devoid of β-lactamase inhibitory activity.

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Authors
  1. Oludotun A. Phillips
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  2. Eduardo L. Setti
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  3. Andhe V. N. Reddy
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  4. Ronald G. Micetich
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  5. Chieko Kunugita
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  6. Akio Hyodo
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  7. Samarendra N. Maiti
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Additional information

SynPhar Laboratories Inc., #2, 4290-91A Street, Edmonton, Alberta T6E 5V2, Canada. Tokushima Research Institute, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno Hiraishi, Kawauchi-cho, Tokushima 771-01, Japan. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1548–1552, November, 1998.

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Phillips, O.A., Setti, E.L., Reddy, A.V.N. et al. Studies on monobactams II. Synthesis and β-lactamase inhibitory activity of 4α-methyl-3-[(thien-2-yl)-methylene]-2-azetidinone-1-sulfonate. Chem Heterocycl Compd 34, 1319–1323 (1998). https://doi.org/10.1007/BF02256812

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  • DOI: https://doi.org/10.1007/BF02256812

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