Abstract
A series of 7α-methoxy-2-[(substituted)methylene]cephem sulfones was synthesized. The compounds with an acetoxy group at the C-3′ position as a leaving group were found to be potent inhibitors of HLE. Selected compounds are also found to be antithrombin agents.
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SynPhar Laboratories Inc. #2 Taiho Alberta Centre, 4290-91A Street, Edmonton, Canada T6E 5V2. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1510–1516, November, 1998.
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Reddy, A.V.N., Fiakpui, C.Y., Czajkowski, D.P. et al. 7α-methoxy-2-[(substituted)methylene]cephem sulfones as inhibitors of human leukocyte elastase and thrombin. Chem Heterocycl Compd 34, 1282–1288 (1998). https://doi.org/10.1007/BF02256808
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DOI: https://doi.org/10.1007/BF02256808