Chemistry of Heterocyclic Compounds

, Volume 34, Issue 11, pp 1276–1281 | Cite as

Sulfones of 7-silyl- and 7-germylcephalosporanates

  • G. Veinberg
  • M. Vorona
  • D. Mucel'
  • Kh. Kazhoka
  • I. Shestakova
  • I. Kanepe
  • I. Domracheva
  • A. Strakov
  • E. Lukevics
Article
  • 24 Downloads

Abstract

7-Silyl- and 7-germylcephalosporanates in the form of a mixture of 7a and 7b stereoisomers were prepared by the interaction of hydrosilanes and a hydrogermane* with sulfones of tert-butyl esters of 7-diazocephalosporanic acid and 7-diazodesacetoxycephalosporanic acid in the presence of rhodium diacetate. Some of the synthesized substances manifest cytotoxic effects in relation to tumor cellsin vitro, and also inhibit the catalytic activity of the enzyme elastase.

Keywords

Enzyme Ester Sulfone Organic Chemistry Catalytic Activity 

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References

  1. 1.
    R. T. Buck, M. P. Doyle, M. J. Drysdale, L. Ferris, D. C. Forbes, D. Haigh, C. J. Moody, N. D. Pearson, and Q. L. Zhou, Tetrahedron Lett.,37, 7631 (1996).Google Scholar
  2. 2.
    Y. Hatanaka, M. Watanabe, S. Onozawa, M. Tanaka, and H. Sakurai, J. Org. Chem.,63, 422 (1998).Google Scholar
  3. 3.
    P. Bulugahapitiya, Y. Landais, L. Parra-Rapado, D. Planchenault, and V. Weber, J. Org. Chem.,62, 1630 (1997).Google Scholar
  4. 4.
    T. J. Blacklock, J. W. Butcher, P. Sohar, T. R. Lamanec, and E. J. J. Grabowski, J. Org. Chem.,54, 3907 (1989).Google Scholar
  5. 5.
    G. Veinberg, I. Shestakova, L. Petrulanis, N. Grigan, D. Musel, D. Zeile, I. Kanepe, I. Domrachova, I. Kalvinsh, A. Strakovs, and E. Lukevics, Bioorg. Med. Chem. Lett.,7, 843 (1997).Google Scholar
  6. 6.
    P. J. Freshliey, Culture of Animal Cells (A Manual of Basic Technique), Wiley, New York (1994), p. 296.Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • G. Veinberg
  • M. Vorona
  • D. Mucel'
  • Kh. Kazhoka
  • I. Shestakova
  • I. Kanepe
  • I. Domracheva
  • A. Strakov
  • E. Lukevics

There are no affiliations available

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