Gastrointestinal Radiology

, Volume 1, Issue 1, pp 67–80 | Cite as

Lesions associated with familial polyposis coli: Studies of lesions of the stomach, duodenum, bones, and teeth

  • Kyosuke Ushio
  • Michizo Sasagawa
  • Hidetaka Doi
  • Tatsuya Yamada
  • Heizaburo Ichikawa
  • Keiichi Hojo
  • Yasuo Koyama
  • Ryozo Sano


The entire gastrointestinal tract and bones were examined systematically in 24 patients (10 pedigrees) in whom familial polyposis coli was diagnosed. Polypoid lesions were observed in the stomach in as high as 68.2% of the cases, and in the duodenum in 90%. Abnormalities were noted in the skeleton in 50% and in the mandible in 81.3%. The authors emphasize the possibility that familial polyposis coli is substantially the same entity as Gardner's Syndrome.

Key words

Familial polyposis coli Stomach Duodenum Bones Teeth Gardner's syndrome 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mayo CW, DeWeerd JH, Jackman RJ: Diffuse familial polyposis of the colon.Surg Gynecol Obstet 93: 87–96, 1951Google Scholar
  2. 2.
    Cripps WH: Two cases of disseminated polypus of the rectum.Trans Pathol Soc London 33: 165, 1882 (Quoted by Mayo)Google Scholar
  3. 3.
    Lockhart-Mummery JP, Dukes CE: Familial adenomatosis of colon and rectum, its relationship to cancer.The Lancet 2: 586–589, 1939Google Scholar
  4. 4.
    Lockhart-Mummery HE, Dukes CE, Bussey HJR: Surgical treatment of familial polyposis of the colon.Br J Surg 43: 476–481, 1956Google Scholar
  5. 5.
    Dukes CE: Familial intestinal polyposis.Ann Eugenics 17: 1–29, 1958Google Scholar
  6. 6.
    Gardner EJ, Stephens FE: Cancer of the lower digestive tract in one family group.Am J Hum Genet 2: 41–48, 1950Google Scholar
  7. 7.
    Gardner EJ: A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum.Am J Hum Genet 3: 167–176, 1951Google Scholar
  8. 8.
    Gardner EJ, Plenk HP: Hereditary pattern for multiple osteomas in a family group.Am J Hum Genet 4: 31–36, 1952Google Scholar
  9. 9.
    Gardner EJ, Richards RC: Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis.Am J Hum Gen 5: 139–147, 1953Google Scholar
  10. 10.
    Smith WG: Multiple polyposis, Gardner's syndrome, and desmoid tumors.Dis Colon Rectum 1: 323–332, 1958Google Scholar
  11. 11.
    Fader M, Kline SN, Spatz SS, Zubrow HJ: Gardner's syndrome (intestinal polyposis, osteomas, sebaceous cysts) and a new dental discovery.Oral Surg 15: 153–172, 1962Google Scholar
  12. 12.
    Wennstrom J, Pierce ER, McKusick VA: Hereditary benign and malignant lesions of the large bowe.Cancer 34: Suppl: 850–857, 1974Google Scholar
  13. 13.
    McColl I, Bussey HJR, Morson BC:Disease of the Colon, Rectum and Anus. London, Heinemann, 1969, pp. 91–103Google Scholar
  14. 14.
    Weary PE, Linthicum A, Cawley EP, et al: Gardner's syndrome. A family group study and review.Arch Dermatol 90: 20–30, 1964Google Scholar
  15. 15.
    Hoffmann DC, Goligher JC: Polyposis of the stomach and small intestine in association with familial polyposis coli.Br J Surg 58: 126–128, 1971Google Scholar
  16. 16.
    Halsted JA, Harris EJ, Bartlett MK: Involvement of the stomach in a familial polyposis of the gastrointestinal tract.Gastroenterology 15: 763–770, 1950Google Scholar
  17. 17.
    Utsunomiya J, Maki T, Iwama T, et al: Gastric lesions of familial polyposis coli.Cancer 34: 745–754, 1974Google Scholar
  18. 18.
    Ushio K, Ichikawa H, Yamada T, et al: Lesions associated with on the so-called familial polyposis of the colon (on lesion of the stomach, bones and teeth).Stomach Intestine 9: 1137–1148, 1974Google Scholar
  19. 19.
    Ohsato K, Watanabe H, Yao T, et al: Simultaneous occurrence of multiple gastric carcinoma and familial polyposis of the colon.Jap J Surg 4: 165–174, 1974Google Scholar
  20. 20.
    Murphy ES, Mireles MV, Beltran AO: Familial polyposis of the colon and gastric carcinoma. Concurrent conditions in a 16-year-old boy.JAMA 179: 1026–1028, 1962Google Scholar
  21. 21.
    Yamada S, Takahashi T: Familial polyposis of the large intestine.Japan J Cancer Clin 17: 676–686, 1971Google Scholar
  22. 22.
    Parks TG, Bussey HJR, Lockhart-Mummery HE: Familial polyposis coli associated with extracolonic abnormalities.Gut 11: 323–329, 1970Google Scholar
  23. 23.
    Cabot RC: Case Records of the Massachusetts General Hospital.N Engl J Med 212: 263–267, 1935Google Scholar
  24. 24.
    MacDonald JM, Davis WC, Crago HR, et al: Gardner's syndrome and periampullary malignancy.Am J Surg 113: 425–430, 1967Google Scholar
  25. 25.
    Schnur PL, David E, Brown PW Jr, et al: Adenocarcinoma of the duodenum and the Gardner syndrome.JAMA 223: 1229–1232, 1973Google Scholar
  26. 26.
    Duncan BR, Dohner VA, Priest JH: The Gardner Syndrome: need for early diagnosis.J Paediat 72: 497–505, 1968Google Scholar
  27. 27.
    Turcot J, Depres J, Pierre F: Malignant tumors of central nervous system associated with familial polyposis of the colon. report of two cases.Dis Colon Rectum 2: 465–468, 1959Google Scholar
  28. 28.
    Yaffee HS: Gastric polyposis and soft tissue tumors, A variant of Gardner's syndrome.Arch Dermatol 89: 806–808, 1964Google Scholar
  29. 29.
    Camiel MR, Mule JE, Alexander LL, et al: Association of the thyroid carcinoma with Gardner's syndrom in siblings.N Engl J Med 278: 1056–1058, 1968Google Scholar
  30. 30.
    Baughman FA Jr, List CR, Williams JR, et al: The Glioma-Polyposis Syndrome.N Engl J Med 281: 1345–1346, 1969Google Scholar
  31. 31.
    McKusick VA, Baltimore: Genetic factors in intestinal polyposis.JAMA 182:271–277, 1962Google Scholar
  32. 32.
    Smith WG, Kern BB: The nature of the mutation in familial multiple polyposis, papillary carcinoma of the thyroid, brain tumors, and familial multiple polyposis.Dis Colon Rectum 16: 264–271, 1973Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Kyosuke Ushio
    • 1
  • Michizo Sasagawa
    • 1
  • Hidetaka Doi
    • 1
  • Tatsuya Yamada
    • 1
  • Heizaburo Ichikawa
    • 1
  • Keiichi Hojo
    • 1
  • Yasuo Koyama
    • 1
  • Ryozo Sano
    • 1
  1. 1.Dept. of Diagnostic RadiologyNational Cancer Center HospitalTokyoJapan

Personalised recommendations