Gastrointestinal Radiology

, Volume 1, Issue 1, pp 59–65 | Cite as

Selective intraarterial infusion of vasopressin for control of gastrointestinal bleeding: Experience with 35 cases

  • G. Leland Melson
  • Guillermo Geisse
  • Robert J. Stanley


Selective intraarterial infusion of vasopressin was performed in 32 patients for 35 episodes of gastrointestinal bleeding. Active bleeding was from esophageal varices in 11 cases and from an arterial site in 22 (stomach 11, duodenum 1, jejunum 2, colon 7, liver 1), including a jejunal diverticulum and a colonic ulcer in Behcet's disease. Two patients, not actively bleeding, were infused for portal decompression before an elective mesocaval shunt. Active bleeding was controlled in 64% of patients with variceal hemorrhage and in 59% of those with arterial sources. Infusion periods ranged from 15 minutes to 70 hours. There were no significant complications directly attributable to this therapy.

Key words

Gastrointestinal bleeding Vasopressin Arteriography 


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  1. 1.
    Baum S, Stein GN, Nusbaum M, et al.: Selective arteriography in the diagnosis of hemorrhage in the gastrointestinal tract.Radiol Clin North Am 7:131–145, 1969Google Scholar
  2. 2.
    Stanley RJ, Wise L: Arteriography in diagnosis of acute gastrointestinal tract bleeding.Arch Surg 107:138–144, 1973Google Scholar
  3. 3.
    Nusbaum M, Baum S, Kuroda K, et al.: Control of portal hypertension by selective mesenteric arterial drug infusion.Arch Surg 97:1005–1013, 1968Google Scholar
  4. 4.
    Nusbaum M, Baum S, Sakiyalak P, et al.: Pharmacologic control of portal hypertension.Surgery 62:299–310, 1967Google Scholar
  5. 5.
    Athanasoulis CA, Baum A, Waltman AC, et al.: Control of acute gastric mucosal hemorrhage.N Engl J Med 290:597–603, 1974Google Scholar
  6. 6.
    Baum S, Athanasoulis CA, Waltman AC, et al.: Gastrointestinal hemorrhage: angiographic diagnosis and control.Ad Surg 7:149–198, 1973Google Scholar
  7. 7.
    Baum S, Nusbaum M: The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin.Radiology 98:497–505, 1971Google Scholar
  8. 8.
    Baum S, Rösch J, Dotter CT, Ring EJ, et al.: Selective mesenteric arterial infusions in the management of massive diverticular hemorrhage.N Engl J Med 288:1269–2973, 1973Google Scholar
  9. 9.
    Brant B, Rosch J, Krippaehne WW: Experiences with angiography in diagnosis and treatment of acute gastrointestinal bleeding of various etiologies: preliminary report.Ann Surg 176:419–433, 1972Google Scholar
  10. 10.
    Conn HO, Ramsby GR, Storer EH: Selective intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage.Gastroenterology 63:634–645, 1972Google Scholar
  11. 11.
    Nusbaum M, Baum S, Blakemore WS: Clinical experience with the diagnosis and management of gastrointestinal hemorrhage by selective mesenteric catheterization.Ann Surg 170:506–514, 1969Google Scholar
  12. 12.
    Rösch J, Dotter CT, Antonovic R: Selective vasoconstrictor infusion in the management of arterio-capillary gastrointestinal hemorrhage.Am J Roentgenol 116:279–288, 1972Google Scholar
  13. 13.
    Rösch J, Gray RK, Grollman JH, Ross G, et al.: Selective arterial drug infusions in the treatment of acute gastrointestinal bleeding.Gastroenterology 59:341–349, 1970Google Scholar
  14. 14.
    Child CG, III:Portal Hypertension. Philadelphia: WB Saunders, 1974, p. 82Google Scholar
  15. 15.
    Stanley RJ, Tedesco FJ, Melson GL, et al.: The colitis of Behcet's disease: A clinical-radiographic correlation.Radiology 114:603–604, 1975Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • G. Leland Melson
    • 1
  • Guillermo Geisse
    • 1
  • Robert J. Stanley
    • 1
  1. 1.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA

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