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Journal of Biomedical Science

, Volume 11, Issue 4, pp 534–537 | Cite as

Decreased total nitric oxide production in patients with duchenne muscular dystrophy

  • Takefumi Kasai
  • Kazuhiro Abeyama
  • Teruto Hashiguchi
  • Hidetoshi Fukunaga
  • Mitsuhiro Osame
  • Kuro Maruyama
Short Communication

Abstract

Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r=−0.384, p=0.0391) in the DMD group. Disruption of NO systems may contribute to the development of muscular dystrophy and have implications for therapeutic strategies.

Key Words

Duchenne muscular dystrophy Dystrophin Nitric oxide nNOS 

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Copyright information

© National Science Council 2004

Authors and Affiliations

  • Takefumi Kasai
    • 1
  • Kazuhiro Abeyama
    • 2
  • Teruto Hashiguchi
    • 2
  • Hidetoshi Fukunaga
    • 3
  • Mitsuhiro Osame
    • 1
  • Kuro Maruyama
    • 2
  1. 1.Department of Neurology and GeriatricsKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  2. 2.Department of Laboratory and Vascular MedicineKagoshima University Graduate School of Medical and Dental SciencesJapan
  3. 3.Department of NeurologyNational Minamikyusyu HospitalKagoshimaJapan

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