Somatic Cell and Molecular Genetics

, Volume 21, Issue 4, pp 285–288 | Cite as

Prevention of DNA 5-methylcytosine reutilization in human cells

  • Juhani A. Vilpo
  • Leena M. Vilpo
Brief Communications


DNA methylation is an important process contributing to transcriptional regulation in animal and plant cells. The well known reutilization of DNA nucleotide bases indicated that DNA degradation occurs in many cells and tissues. On the other hand, the reutilization of 5-methyl-2′-deoxycytidine monophosphate in the DNA synthesis would have deleterious effects on gene regulation. Recent molecular insights into the exclusion of exogenous 5-methylcytosine from DNA are the subject of this review.


Nucleotide Plant Cell Gene Regulation Human Cell Deleterious Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Borek, E., and Srinivasan, P.R. (1966).Annu. Rev. Biochem. 35:275–298.Google Scholar
  2. 2.
    Razin, A., and Riggs, A.D. (1980).Science 210:604–610.Google Scholar
  3. 3.
    Ehrlich, M., and Wang, R.Y.-H. (1981).Science 212:1350–1357.Google Scholar
  4. 4.
    Doerfler, W. (1983).Annu. Rev. Biochem. 52:93–124.Google Scholar
  5. 5.
    Cedar, H. (1988).Cell 53:3–4.Google Scholar
  6. 6.
    Wölfl, S., Schräder, M., and Wittig, B. (1991).Proc. Natl. Acad. Sci. USA 88:271–275.Google Scholar
  7. 7.
    Razin, A., Szyf, M., Kafri, T., Roll, M., Giloh, H., Scarpa, S., Carotti, D., and Cantoni, G.L. (1986).Proc. Natl. Acad. Sci. USA 83:2827–2831.Google Scholar
  8. 8.
    Saluz, H.P., Jiricny, J., and Jost, J.P. (1986).Proc. Natl. Acad. Sci. USA 83:7167–7171.Google Scholar
  9. 9.
    Sullivan, C.H., and Grainger, R.M. (1986).Proc. Natl. Acad. Sci. USA 83:329–333.Google Scholar
  10. 10.
    Paroush, Z., Keshet, I., Yisraeli, J., and Cedar, H. (1990).Cell 63:1229–1237.Google Scholar
  11. 11.
    Kornberg, A. (1974). in:DNA Synthesis, Freeman, San Francisco, California, pp. 46–50.Google Scholar
  12. 12.
    Moyer, J.D., Malinowski, N., and Ayers, O. (1985).J. Biol. Chem. 26:2812–2818.Google Scholar
  13. 13.
    Vilpo, J.A., and Vilpo, L.M. (1989).Nucleosides and Nucleotides 8:979–982.Google Scholar
  14. 14.
    Vilpo, J.A., Rasi, S., Suvanto, E., and Vilpo, L.M. (1986).Anal. Biochem. 154:436–440.Google Scholar
  15. 15.
    Dudman, N.P., Deveski, W.B., and Tattersall, M.H. (1981).Anal. Biochem. 115:428–437.Google Scholar
  16. 16.
    Ross, D.D., Akman, S.A., Schecker, A.W., and Bachur, N.R. (1981).Cancer Res. 41:4493–4498.Google Scholar
  17. 17.
    Peters, G.J., De Abreu, R.A., Oosterhof, A., and Veerkamp, J.H. (1983).Biochim. Biophys. Acta 759:7–15.Google Scholar
  18. 18.
    Cooper, G.M., and Greer, S. (1973).Mol. Pharmacol. 9:698–703.Google Scholar
  19. 19.
    Eriksson, S., Kierdaszuk, B., Munch-Petersen, B., Öberg, B., and Johansson, N.G. (1991).Biochem. Biophys. Res. Commun. 176:586–592.Google Scholar
  20. 20.
    Jekunen, A., Puukka, M., and Vilpo, J.A. (1983).Biochem. Pharmacol. 32:1165–1168.Google Scholar
  21. 21.
    Fox, L., Dobersen, M.J., and Greer, S. (1983).Antimicrob. Agents Chemother. 23:465–476.Google Scholar
  22. 22.
    Adams, R.L.P., Fulton, J., and Kirk, D. (1982).Biochim. Biophys. Acta 697:286–294.Google Scholar
  23. 23.
    Jekunen, A., and Vilpo, J.A. (1984).Mol. Pharmacol. 25:431–435.Google Scholar
  24. 24.
    Jekunen, A., and Vilpo, J.A. (1984b).J. Natl. Cancer Inst. 73:1087–1091.Google Scholar
  25. 25.
    Vilpo, J.A., and Vilpo, L.M. (1993).Mutation Res. 286:217–220.Google Scholar
  26. 27.
    Nyce, J. (1991).Somat. Cell Mol. Genet. 17:543–550.Google Scholar
  27. 28.
    Holliday, R., and Ho, T. (1991).Somat. Cell Mol. Genet. 17:537–542.Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Juhani A. Vilpo
    • 1
  • Leena M. Vilpo
    • 1
  1. 1.Laboratory of Molecular Hematology, Department of Clinical ChemistryTampere University HospitalTampereFinland

Personalised recommendations