Journal of Biomedical Science

, Volume 4, Issue 2–3, pp 91–97 | Cite as

Participation of galaninergic neurotransmission at the paraventricular hypothalamic nucleus in the suppression of baroreceptor reflex response by locus ceruleus in the rat

  • Nien-Chung Yang
  • Samuel H. H. Chan
  • Julie Y. H. Chan
Original Paper

Abstract

We evaluated the potential participation of galanin (GAL) at the paraventricular nucleus of hypothalamus (PVN) in the suppression of baroreceptor reflex (BRR) response by locus ceruleus (LC), using adult male Sprague-Dawley rats anesthetized with pentobarbital sodium. Microinjection of GAL (100 pmol) bilaterally into the PVN significantly depressed the BRR response. This suppressive effect was appreciably antagonized when GAL (100 pmol) and GAL antiserum (1:20) were coadministered into the bilateral PVN. Whereas bilateral microinjection of GAL antiserum into the PVN by itself elicited minimal effect, it nevertheless significantly attenuated the suppressive effect of either electrical or chemical activation of LC on the BRR response. Pretreatment with the same amount of normal rabbit serum (1:20), on the other hand, was ineffective. These results suggest that a galaninergic projection from the LC to PVN may participate in the suppression of BRR response by this dorsal pontine nucleus.

Key Words

Galanin Locus ceruleus Paraventricular nucleus of hypothalamus Baroreceptor reflex response Galanin antiserum Nucleus tractus solitarii 

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Copyright information

© National Science Coucil 1997

Authors and Affiliations

  • Nien-Chung Yang
    • 1
  • Samuel H. H. Chan
    • 2
  • Julie Y. H. Chan
    • 1
  1. 1.Department of Medical ResearchVeterans General Hospital TaipeiTaipeiTaiwan (Republic of China)
  2. 2.Center for NeuroscienceNational Yang-Ming UniversityTaipeiTaiwan

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