Somatic Cell and Molecular Genetics

, Volume 20, Issue 4, pp 345–351 | Cite as

Regional localization ofDPP4 (aliasCD26 andADCP2) to chromosome 2q24

  • Dalila Darmoul
  • Margaret Fox
  • Clare Harvey
  • Penny Jeggo
  • James R. Gum
  • Young S. Kim
  • Dallas M. Swallow
Brief Communication

Abstract

A panel of microcell hybrids containing fragments of chromosome 2 was analyzed for the presence of humanDPP4, the gene that codes for dipeptidyl peptidase IV (or CD26), by specific PCR amplification of a fragment of the 3′ untranslated region of the gene. This analysis placedDPP4 betweenLCT andGAD in bands q21 to q31. The localization was confirmed by in situ hybridization using two genomic probes that each revealed a hybridization signal in band q24. We also use the recent identification of the ADA binding protein as DPPIV to propose that the geneADCP2 should be renamedDPP4.

Keywords

Untranslated Region Regional Localization Chromosome 2q24 Hybridization Signal Dipeptidyl Peptidase 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Dalila Darmoul
    • 1
    • 2
  • Margaret Fox
    • 2
  • Clare Harvey
    • 2
  • Penny Jeggo
    • 3
  • James R. Gum
    • 4
  • Young S. Kim
    • 5
  • Dallas M. Swallow
    • 2
  1. 1.INSERM U410, Neuroendocrinologie et Biologie Cellulaire DigestivesFaculté de Médécine Xavier BichatPARISFrance
  2. 2.The Galton LaboratoryMRC Human Biochemical Genetics Unit (UCL)LondonU.K.
  3. 3.MRC Cell Mutation UnitUniversity of SussexBrightonU.K.
  4. 4.Department of Anatomy, University of California Service, Gastrointestinal Research Laboratory(151M2) V.A. Medical CenterSan Francisco
  5. 5.Department of Medicine, University of California Service, Gastrointestinal Research Laboratory151M2) V.A. Medical CenterSan Francisco

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