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Regional localization ofDPP4 (aliasCD26 andADCP2) to chromosome 2q24

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Somatic Cell and Molecular Genetics

Abstract

A panel of microcell hybrids containing fragments of chromosome 2 was analyzed for the presence of humanDPP4, the gene that codes for dipeptidyl peptidase IV (or CD26), by specific PCR amplification of a fragment of the 3′ untranslated region of the gene. This analysis placedDPP4 betweenLCT andGAD in bands q21 to q31. The localization was confirmed by in situ hybridization using two genomic probes that each revealed a hybridization signal in band q24. We also use the recent identification of the ADA binding protein as DPPIV to propose that the geneADCP2 should be renamedDPP4.

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Authors and Affiliations

  1. INSERM U410, Neuroendocrinologie et Biologie Cellulaire Digestives, Faculté de Médécine Xavier Bichat, 16 rue Henri Huchard, 75018, PARIS, France

    Dalila Darmoul

  2. The Galton Laboratory, MRC Human Biochemical Genetics Unit (UCL), Wolfson House, 4 Stephenson Way, NW1 2HE, London, U.K.

    Dalila Darmoul, Margaret Fox, Clare Harvey & Dallas M. Swallow

  3. MRC Cell Mutation Unit, University of Sussex, Falmer, BN1 9RR, Brighton, U.K.

    Penny Jeggo

  4. Department of Anatomy, University of California Service, Gastrointestinal Research Laboratory, (151M2) V.A. Medical Center, 4150, Clement Street, 94121, San Francisco, California

    James R. Gum

  5. Department of Medicine, University of California Service, Gastrointestinal Research Laboratory, 151M2) V.A. Medical Center, 4150, Clement Street, 94121, San Francisco, California

    Young S. Kim

Authors
  1. Dalila Darmoul
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  2. Margaret Fox
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  3. Clare Harvey
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  4. Penny Jeggo
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  5. James R. Gum
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  6. Young S. Kim
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  7. Dallas M. Swallow
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Darmoul, D., Fox, M., Harvey, C. et al. Regional localization ofDPP4 (aliasCD26 andADCP2) to chromosome 2q24. Somat Cell Mol Genet 20, 345–351 (1994). https://doi.org/10.1007/BF02254723

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  • DOI: https://doi.org/10.1007/BF02254723

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