Pediatric Nephrology

, Volume 9, Issue 3, pp 278–281 | Cite as

Vitamin D metabolites in childhood nephrotic syndrome

  • Annick Grymonprez
  • Willem Proesmans
  • Maria Van Dyck
  • Ivo Jans
  • G. Goos
  • Roger Bouillon
Original Article

Abstract

We measured serum levels of total and ionised calcium, phosphate, intact parathyroid hormone, 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D] and the vitamin D binding protein (DBP) in 14 children with idiopathic nephrotic syndrome and 10 healthy, age-matched controls. In all nephrotics serum DBP levels were below the normal range. Serum 25(OH)D was below 7 ng/ml in 10 of 14 nephrotic children and in the low normal range in the remaining 4 patients. The average serum 1,25(OH)2D levels were lower in the nephrotic patients than in the controls. However, free 1,25(OH)2D levels were normal in the nephrotic patients. Both serum 25(OH)D and 1,25(OH)2D correlated positively with the concentration of DBP There was a significant negative correlation between serum DBP levels and the urinary protein excretion and a significant positive correlation between the urinary excretions of DBP and albumin. From this study it can be concluded that the nephrotic child is capable of maintaining appropriate serum concentrations of free calcitriol despite important urinary losses of both substrate and bound calcitriol.

Key words

Nephrotic syndrome Vitamin D 25-hydroxyvitamin D Parathyroid hormone 1,25-dihydroxyvitamin D 

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Copyright information

© IPNA 1995

Authors and Affiliations

  • Annick Grymonprez
    • 1
  • Willem Proesmans
    • 1
  • Maria Van Dyck
    • 1
  • Ivo Jans
    • 2
  • G. Goos
    • 1
  • Roger Bouillon
    • 2
  1. 1.Department of PaediatricsUniversity of LeuvenLeuvenBelgium
  2. 2.Laboratory for Experimental Medicine and EndocrinologyUniversity of LeuvenLeuvenBelgium

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