Pflügers Archiv

, Volume 431, Issue 5, pp 741–747 | Cite as

Effects of endotoxin infusion on mean systemic filling pressure and flow resistance to venous return

  • Michael Hiesmayr
  • Jos R. C. Jansen
  • Adrian Versprille
Original Article


Mean systemic filling pressure (Psf) is an indicator of the filling state of the systemic circulation. Cardiac output (Q′) is related linearly to the difference betweenPsf and central venous pressure (Pcv), according to:Q′ = (PsfPcv)/Rsf, whereRsf is the flow resistance downstream from the sites where blood pressure is equal toPsf In 16 anaesthetized pigs we evaluatedPsf,Rsf andQ′ during baseline conditions, continuous endotoxin infusion and after subsequent fluid loading.Psf andRsf were determined from simultaneous measurements ofQ′ andPcv at seven levels of lung inflation. The following results were obtained.Psf was 8.1 ±1.8 mm Hg (mean ± SD) during baseline conditions, increased after endotoxin infusion to 9.9 ± 3.2 mm Hg (P = 0.04) and remained the same after infusion of 18 ml · kg−1 of Ringer's lactate.Rsf increased from 0.34 ± 0.07 to 0.80 ± 0.34 mm Hg · ml−1 · s by endotoxin and decreased after fluid infusion to 0.58 ± 0.14.Q′ changed inversely proportional toRsf (P = 0.001).Rsf changes were highly correlated with the changes in total systemic flow resistance (RS) (P < 0.001). Endotoxin caused haemoconcentration and a decrease in plasma volume. The stability ofPsf during endotoxin infusion and after volume loading indicate that the stressed volume was well maintained and changes in blood volume are compensated by changes in nonstressed volume. The increase inRsf can be attributed to arteriolar vasoconstriction, venous vasoconstriction and haemoconcentration.

Key words

Endotoxin Venous return Systemic filling pressure Vascular resistance Stressed volume 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Michael Hiesmayr
    • 2
  • Jos R. C. Jansen
    • 1
  • Adrian Versprille
    • 1
  1. 1.Pathophysiological Laboratory, Department of Pulmonary DiseasesErasmus UniversityRotterdamThe Netherlands
  2. 2.Department of Cardiothoracic Anaesthesia and Intensive CareUniversity of ViennaAustria

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