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Psychopharmacology

, Volume 111, Issue 4, pp 402–408 | Cite as

Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration

  • William A. CarlezonJr
  • Roy A. Wise
Original Investigations

Abstract

Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the “dose” of stimulation required to maintain responding at a given criterion. No progressive changes in the reward-potentiating effects of PCP were evident when the rats were tested once per week for 8 weeks; there was neither tolerance nor sensitization to the initial rewarding properties of PCP. However, in subsequent locomotor tests rats appeared to be already sensitized to PCP; this raises the possibility that the electrical stimulation of the lateral hypothalamus itself maximally sensitized the animals to the stimulant effects of the drug.

Key words

Phencyclidine Brain stimulation reward Lateral hypothalamus Locomotion Sensitization 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • William A. CarlezonJr
    • 1
  • Roy A. Wise
    • 1
  1. 1.Center for Studies in Behavioral Neurobiology, Department of PsychologyConcordia UniversityMontrealCanada

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