Journal of Biomedical Science

, Volume 2, Issue 3, pp 237–241 | Cite as

Inhibin and activin modulate transforming growth factor-β-induced immunosuppression

  • Shao-Yao Ying
  • Ann Becker
Original Paper

Abstract

Inhibin, activin, and transforming growth factor β (TGFβ) inhibited lipopoly-saccharide (LPS)-induced lymphocyte proliferation in a dose-dependent fashion. These induced suppressions were neutralized by coincubation of a preparation of antibodies to inhibin and TGFβ, respectively. Inhibin and activin also facilitated TGFβ-mediated immunosuppression of LPS-induced proliferation of splenocytes. These gonadal proteins showed no effect on phytohemagglutinin-or concanavalin A (Con-A)-induced proliferation of lymphocytes. However, inhibin facilitated and activin inhibited the TGFβ-mediated immunosuppression in thymocytes stimulated by Con-A. These findings suggest that inhibin or activin by itself, and/or together with TGFβ, may play an important role in immune response.

Key Words

Activin Inhibin TGFβ Immunosuppression B cells T cells 

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Copyright information

© National Science Council 1995

Authors and Affiliations

  • Shao-Yao Ying
    • 1
  • Ann Becker
    • 1
  1. 1.Department of Cell and NeurobiologyUniversity of Southern California School of MedicineLos AngelesUSA

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