Inhibin and activin modulate transforming growth factor-β-induced immunosuppression
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Inhibin, activin, and transforming growth factor β (TGFβ) inhibited lipopoly-saccharide (LPS)-induced lymphocyte proliferation in a dose-dependent fashion. These induced suppressions were neutralized by coincubation of a preparation of antibodies to inhibin and TGFβ, respectively. Inhibin and activin also facilitated TGFβ-mediated immunosuppression of LPS-induced proliferation of splenocytes. These gonadal proteins showed no effect on phytohemagglutinin-or concanavalin A (Con-A)-induced proliferation of lymphocytes. However, inhibin facilitated and activin inhibited the TGFβ-mediated immunosuppression in thymocytes stimulated by Con-A. These findings suggest that inhibin or activin by itself, and/or together with TGFβ, may play an important role in immune response.
Key WordsActivin Inhibin TGFβ Immunosuppression B cells T cells
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