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Inflammation Research

, Volume 45, Issue 8, pp 428–433 | Cite as

Release of histamine in whole blood by oxygen radicals: Division between specific and unspecific processes

  • B. Poch
  • F. Gansauge
  • S. Gansauge
  • T. Anger
  • U. Nilsson
  • M. H. Schoenberg
  • H. G. Beger
Original Research Papers

Abstract

Oxygen derived free radicals are involved in many pathological processes such as postischemic reperfusion injuries, hepatotoxicity of drugs and inflammatory processes. Thereby these oxygen radicals induce lipid peroxidation and perturbation of cellular membranes. The aim of our present study was to determine whether oxygen radicals generated by the xanthine oxidase/hypoxanthine system cause a release of histamine in human blood cell cultures. Stimulation of blood cell cultures with oxygen radicals induced a histamine liberation which was mainly due to calcium independent processes during the first 30 min, whereas then calcium requiring processes took part in the release of histamine. The regulation of the leukocyte selectin LECAM-1 was altered by oxygen radicals whereas histamine, which is known to modulate vascular selectin expression, did not affect the expression of LECAM-1. Our data indicate that oxygen radicals induce a direct calcium independent release of histamine which is due to membrane pertubating processes during the first phase but also induce a specific reaction leading to a further indirect histamine liberation which is probably mediated by PAF.

Key words

Histamine Oxygen radicals PAF LECAM-1 Calcium 

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References

  1. [1]
    Uvnäs B, Thon IL. A physico-chemical model of histamine release from mast cells. In: Von Euler U, Rosell K, Uvnäs B, editors. Mechanisms of release of Biogenic amines. Oxford: Pergamon Press, 1966:361–71.Google Scholar
  2. [2]
    Uvnäs B, Aborg CH, Bergendorff A. Storage of histamine in mast cells. Evidence for an ionic binding of histamine to protein carboxyls in the granule heparin-protein complex. Acta Physiol Scand 1970;78:1.PubMedGoogle Scholar
  3. [3]
    Masini E, Fantozzi R, Bladina P, Brunelleschi S, Mannaioni PF. The riddle of cholinergic histamine release. Prog Med Chem 1986;22:268–88.Google Scholar
  4. [4]
    Foreman JC, Hallett MB, Mongar JL. The relationship between histamine secretion and calcium uptake by mast cells. J Physiol 1977;271:193–214.PubMedGoogle Scholar
  5. [5]
    Kazimierczak W, Diamant B. Mechanisms of histamine release in anaphylactic and anaphylactoid reactions. Prog Allergy 1978;24:295–365.PubMedGoogle Scholar
  6. [6]
    McCord JM, Oxygen derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159–63.PubMedGoogle Scholar
  7. [7]
    Ryle PR. Free radicals, lipid peroxidation and ethanol hepatotoxicity. Lancet 1984;ii:461.CrossRefGoogle Scholar
  8. [8]
    Milei J, Boveris A, Llesuy S, Molina HA, Storino R, Ortega D, et al. Amelioration of adriamycin-induced cardiotoxicity in rabbits by prenylamine and vitamins A and E. Am Heart J 1986;111:95–102.CrossRefPubMedGoogle Scholar
  9. [9]
    McCord JM. The biochemistry and pathophysiology of superoxide. Physiologist 1983;26:165–9.PubMedGoogle Scholar
  10. [10]
    Thompson JA, Hess ML. The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis. Prog Cardiovasc Dis 1986;28:449–62.CrossRefPubMedGoogle Scholar
  11. [11]
    Davies KJ. Protein damage and degradation by oxygen radicals. 1. General aspects. J Biol Chem 1987;262:9895–901.PubMedGoogle Scholar
  12. [12]
    Slater TF. Free radical mechanism in tissue injury. Biochem J 1984;222:1–15.PubMedGoogle Scholar
  13. [13]
    Ohmori H, Komoriya K, Azuma A, Hashimoto Y Kurozumi S. Xanthine oxidase induced histamine foot edema in rats: involvement of oxygen radicals. Biochem Pharmacol 1978;27:1397–400.CrossRefPubMedGoogle Scholar
  14. [14]
    Ohmori H, Komoriya K, Azuma A, Kurozomi S, Hashimoto Y. Xanthine oxidase-induced histamine release from isolated rat peritoneal cells: involvement of hydrogen peroxide. Biochem Pharmacol 1979;28:333–4.CrossRefPubMedGoogle Scholar
  15. [15]
    Stendahl O, Molin L, Lindroth M. Granulocyte-mediated release of histamine from mast cells. Int Archs Allergy Appl Immunol 1983;70:277–84.Google Scholar
  16. [16]
    Mannaioni PF, Giannella E, Palmerani B, Pistelli A, Gambassi F, Bani-Sacchi T, et al. Plenary lecture: Free radicals as endogeneous histamine releasers. Agents Actions 1988;23:129–42.CrossRefPubMedGoogle Scholar
  17. [17]
    Patel KD, Zimmermann GA, Prescott SM, McEver RP, McIntyre TM. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 1991;122:749–59.CrossRefGoogle Scholar
  18. [18]
    Lo SK, Janakidevi K, Lai L, Malik AB. Hydrogen peroxide-induced increase in endothelial adhesiveness in dependent on ICAM-1 activation. Am J Physiol 1993;264:L406–12.PubMedGoogle Scholar
  19. [19]
    Zimmerman GA, McIntyre TM, Prescott SM. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J Clin Invest 1985;76:2235–46.PubMedGoogle Scholar
  20. [20]
    Lorenz W, Reimann HJ, Barth H, Kusche J, Meyer R, Doenicke A, et al. A sensitive and specific method for the determination of histamine in whole blood and plasma. Z Physiol Chem 1972;353:911–20.PubMedGoogle Scholar
  21. [21]
    Fredholm BB, Sollevi A. The release of adenosine and inosine from subcutaneous adipose tissue by nerve stimulation and noradrenaline. J Physiol 1981;313:251–67.PubMedGoogle Scholar
  22. [22]
    Schoenberg MH, Poch B, Younes M, Schwarz A, Bazacko K, Lundberg C, et al. Involvement of neutrophils in postischaemic damage to the small intestine. Gut 1991;32:905–12.PubMedGoogle Scholar
  23. [23]
    Uchanska-Ziegler B, Wernet P, Ziegler A. Rapid preparation of multiple cell samples from immunoflourescence samples for immunofluorescence analysis using microtiter plates. J Immunol Meth 1980;39:85–8.CrossRefGoogle Scholar
  24. [24]
    Rauckman EJ, Rosen GM, Abou-Donia MB. Improved methods for the oxidation of secondary amines to nitroxides. Syn Commun 1975;5:409–13.Google Scholar
  25. [25]
    Kemeny L, Ruzicka T, Braun Falco O. Dithranol: a review of the mechanism of action in the treatment of psoriasis vulgaris. Skin Pharmacol 1990;3:1–20.PubMedGoogle Scholar
  26. [26]
    Kemeny L, Csato M, Dobozy A. Pharmacological studies on dithranol-induced irritative dermatitis in mice. Arch Dermatol Res 1989;281:362–5.CrossRefPubMedGoogle Scholar
  27. [27]
    Prescott SM, Zimmerman GA, McIntyre TM. Platelet-activating factor. J Biol Chem 1990;265:17381–4.PubMedGoogle Scholar
  28. [28]
    Prescott SM, McIntyre TM, Zimmerman GA. The role of platelet-activating factor in endothelial cells. Thromb Haemost 1990;64:99–103.Google Scholar
  29. [29]
    Zimmerman GA, Prescott SM, McIntyre TM. Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol Today 1992;13:93–100.CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • B. Poch
    • 1
  • F. Gansauge
    • 1
  • S. Gansauge
    • 1
  • T. Anger
    • 1
  • U. Nilsson
    • 1
  • M. H. Schoenberg
    • 1
  • H. G. Beger
    • 1
  1. 1.Department of General SurgeryUniversity of UlmUlmGermany

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