Chemistry of Heterocyclic Compounds

, Volume 35, Issue 11, pp 1349–1356 | Cite as

Synthesis of 1,4-dihydroimidazo[5,1-c]-1,2,4-triazin-4-ones and imidazo[5,1-c]-1,2,4-triazoles

  • M. A. Bezmaternykh
  • V. S. Mokrushin
  • T. A. Pospelova


Azo compounds obtained by the coupling of 5-diazoimidazoles with diethyl esters of nitro-, chloro-, bromo-, and acetylaminomalonic acids under conditions of base catalysis are cyclized to give 1,4-dihydroimidazo[5,1-c]-1,2,4-triazin-4-ones or imidazo[5,1-c]-1,2,4-triazoles. The chloro, bromo, and nitro groups in the bicyclic products are readily replaced by action of nucleophiles. The imidazotriazinones are converted to chloroimidazotriazines by reaction with thionyl chloride or phosphorus oxychloride


Chloride Ester Phosphorus Organic Chemistry Catalysis 
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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • M. A. Bezmaternykh
  • V. S. Mokrushin
  • T. A. Pospelova

There are no affiliations available

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