Chemistry of Heterocyclic Compounds

, Volume 35, Issue 2, pp 195–198 | Cite as

Reaction of 1,2,3,4-tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl-substituted derivative with nitric acid

  • A. V. Varlamov
  • T. N. Borisova
  • E. A. Sorokina
  • A. I. Chernyshev
Article

Abstract

1,2,3,4-Tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl derivative when treated with nitric acid are converted to substituted tetrahydropyrrolo-[1,2-c]pyrimidine-7-carboxylic acid. Conversion occurs through opening of the aminal moiety and formylation of the second molecule of tetrahydropyrrolo[1,2-c]pyrimidine by formaldehyde formed to the 7-formyl-substituted derivative.

Keywords

Formaldehyde Organic Chemistry Nitric Acid Pyrimidine Aminal Moiety 

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References

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    T. N. Borisova, A. E. Aliev, E. A. Sorokina, A. A. Sinitsyna, and A. V. Varlamov, Khim. Geterotsikl. Soedin., No. 4, 534 (1995).Google Scholar
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    Ts. E. Agadzhanyan, A. D. Arutyunyan, and G. L. Arutyunyan, Khim. Geterotsikl. Soedin., No. 7, 929 (1992).Google Scholar

Copyright information

© Kluwer Academic/Plenum 1999

Authors and Affiliations

  • A. V. Varlamov
  • T. N. Borisova
  • E. A. Sorokina
  • A. I. Chernyshev

There are no affiliations available

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