Chemistry of Heterocyclic Compounds

, Volume 35, Issue 1, pp 101–105 | Cite as

Synthesis of 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1′-cyclohexane and its reaction with dibromoalkanes

  • A. I. Markosyan
  • R. A. Kuroyan
  • S. V. Dilanyan
  • A. Sh. Oganesyan
  • M. S. Aleksanyan
  • A. A. Karapetyan
  • Yu. T. Struchkov
Article

Abstract

4-(N′-Benzoylthioureido)-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1′-cyclohexane), which was synthesized from 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1′-cyclohexane) and benzoyl isothiocyanate, cyclized to give 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1′-cyclohexane). Reaction of the latter with 1,2-dibromoethane or 1,3-dibromopropane gave products of intramolecular dialkylation at the S and N(3) atoms.

Keywords

Organic Chemistry Cyclohexane Isothiocyanate Benzoyl Benzoyl Isothiocyanate 

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References

  1. 1.
    A. I. Markosyan, S. V. Dilanyan, R. A. Kuroyan, A. A. Chachoyan, and B. T. Garibdazhayan, Khim.-Farm. Zh.,29, No. 4, 32 (1995).Google Scholar
  2. 2.
    F. H. Allen, O. Kennard, D. G. Watson, L. Brammer, A. G. Orpen, and R. Taylor, J. Chem. Soc., Perkin Trans II, No. 12, S1 (1987).Google Scholar
  3. 3.
    R. G. Gerr, A. I. Yanovskii, and Yu. T. Struchkov, Kristallografiya,28, 527 (1983).Google Scholar
  4. 4.
    R. A. Kuroyan, A. I. Markosyan, A. Sh. Oganisyan, and M. G. Oganisyan, Arm. Khim. Zh.,42, 527 (1989).Google Scholar

Copyright information

© Kluwer Academic/Plenum 1999

Authors and Affiliations

  • A. I. Markosyan
  • R. A. Kuroyan
  • S. V. Dilanyan
  • A. Sh. Oganesyan
  • M. S. Aleksanyan
  • A. A. Karapetyan
  • Yu. T. Struchkov

There are no affiliations available

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