Abstract
The reactions of 3-methyl-1-(2-pyridyl)-, 3-methyl-1-phenyl-, and 3-methyl-1,6-diphenyl-4-chloro-5-formyl-6,7-dihydroindazoles with guanidine and benzo- and 3- and 4-pyridinecarbamidines gave the corresponding 8-substituted 1-methyl-3-(2-pyridyl)-and 1-methyl-3-phenyl-4,5-dihydropyrazolo[5,4-h]quinazolines. With acetic anhydride the same indazole derivatives gave the 4-acetoxy-5-formyl derivatives, and with hydroxylamine they gave4-chloro-5-hydroxyiminomethyl-6,7-dihydroindazoles. Thereactionof4-acetoxyl-1-(2-pyridyl)-5-formyl-6,7-dihydroindazole with hydroxylamine gave 8-methyl-6-(2-pyridyl)-4,5-dihydroisoxazolo[5,4-e]indazole, while dehydration of 5-hydroxyiminomethyl-3-methyl-4-chloro-6,7-dihydroindazole gave the 4-chloro-5-cyano derivative. The reaction of the latter with nucleophilic reagents was investigated.
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References
I. A. Strakova, L. G. Delyatitskaya, M. V. Petrova, and A. Ya. Strakov, Khim. Geterotsikl. Soedin., No. 6, 768 (1998).
I. A. Strakova, A. Ya. Strakov, and É. Yu. Gudrinietse, Izv. Akad. Nauk Latv. SSR. Ser. Khim., No. 5, 627 (1972).
Additional information
Riga Technical University, Riga, Latvia LV-1658. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1209–1213, September, 1998.
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Strakova, I.A., Delyatitskaya, L.G., Petrova, M.V. et al. Reactions of 3-methyl-1-(2-pyridyl)-4-chloro-5-formyl-6,7-dihydroindazole. Chem Heterocycl Compd 34, 1036–1040 (1998). https://doi.org/10.1007/BF02251548
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DOI: https://doi.org/10.1007/BF02251548