Low doses of atropine sulfate impair retention of a well-learned spatial task

  • T. M. Rauch
  • D. I. Welch
  • L. Gallego


Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40, and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10mg/kg, iv) than have previously been shown to disrupt spatial retention.


Atropine spatial retention dose-response 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • T. M. Rauch
    • 1
  • D. I. Welch
    • 1
  • L. Gallego
    • 1
  1. 1.U.S. Army Research Institute of EnvironmentalNatickU.S.A.

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