Skip to main content
SpringerLink
Log in

D1/D2 dopamine and N-methyl-d-aspartate (NMDA) receptor participation in experimental catalepsy in rats

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Mixed D1/D2 dopamine (DA) antagonists, perphenazine (5 mg/kg) and haloperidol (2 mg/kg) induced catalepsy in rats. SCH 23390 (1 mg/kg), a D1 DA antagonist, also produced catalepsy. Co-administration of perphenazine (0.5 mg/kg) and SCH 23390 (0.1 mg/kg), at low doses, produced a marked increase in cataleptic response. B-HT 920, a D2 agonist, reversed the cataleptogenic effects of perphenazine, haloperidol and SCH 23390. SKF 38893 (5 mg/kg) reduced the cataleptogenic effect of SCH 23390 but failed to reverse haloperidol- or perphenazine-induced catalepsy. SKF 38393 (10 mg/kg), however, protected the animals against perphenazine- induced catalepsy. Combined administration of B-HT 920 (0.1 mg/kg) and SKF 38393 (5 mg/kg) enhanced the protective effect of B-HT 920 in SCH 23390-treated animals but not in animals treated with haloperidol or perphenazine. MK-801 (0.025–0.5 mg/kg), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, reduced the cataleptogenic effects of perphenazine, haloperidol as well as SCH 23390. The anticataleptic action of MK-801 was enhanced by scopolamine (0.1 mg/kg) but not by bromocriptine (1 mg/kg) or clonidine (0.05 mg/kg) in perphenazine-treated rats. Unlike B-HT 920 (0.1 mg/kg), SKF 38393 (5 mg/kg) potentiated the anticataleptic effect of MK-801 (0.01 mg/kg) against SCH 23390-induced catalepsy. The above data suggests D1/D2 interdependence in catalepsy and a modulatory role of D1 and D2 DA receptor stimulation on the anticataleptic effect of MK-801.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arnt J, Perregaard J (1987) Synergistic interaction between dopamine D1 and D2 receptor agonists: circling behaviour of rats with hemitransection. Eur J Pharmacol 143:45–53

    Google Scholar 

  • Arnt J, Hyttel J, Perregaard J (1987) Dopamine D1 receptor agonists combined with the selective D2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats. Eur J Pharmacol 133:137–145

    Google Scholar 

  • Braun AR, Barone P, Chase TN (1986) Interaction of D1 and D2 dopamine receptors in the expression of dopamine agonist induced behaviours. In: Breese GR, Greese I (eds) Neurobiology of central D1 dopamine receptors. Plenum Press, New York pp 151–166

    Google Scholar 

  • Braun AR, Chase TN (1986) Obligatory D1/D2 receptor interaction in the generation of dopamine agonist related behaviours. Eur J Pharmacol 131:301–306

    Google Scholar 

  • Carlsson M, Carlsson A (1989a) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75:221–226

    Google Scholar 

  • Carlsson M, Carlsson A (1989b) Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice. J Neural Transm 77:65–71

    Google Scholar 

  • Carlsson M, Carlsson A (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia — implications for schizophrenia and Parkinson's disease. TINS 13:272–276

    Google Scholar 

  • Clineschmidt BV, Martin GE, Bunting PR, Papp NL (1982) Central sympathomimetic activity of (+)-5-methyl-10, 11-dihydro-5H-dibenzo(a, d) cyclohepten-5, 10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties. Drug Dev Res 2:135–145

    Google Scholar 

  • Clow DW, Jhamandas K (1989) Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen. J Pharmacol Exp Ther 248:722–728

    Google Scholar 

  • Fessler RG, Sturgeon RD, Meltzer HY (1978) Phencyclidine-induced ipsilateral rotation in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra. Life Sci 24:1281–1288

    Google Scholar 

  • French ED, Pilapil C, Quirion R (1985) Phencyclidine binding sites in the nucleus accumbens and phencyclidine-induced hyperactivity are decreased following lesions of the mesolimbic dopamine system. Eur J Pharmacol 116:1–9

    Google Scholar 

  • Hiramatsu M, Cho AK, Nabeshima T (1989) Comparison of the behavioural and biochemical effects of the NMDA receptor antagonists, MK-801 and phencyclidine. Eur J Pharmacol 166:359–366

    Google Scholar 

  • Hjorth S, Carlsson A (1987) Postsynaptic dopamine (DA) receptor stimulator properties of the putative DA autoreceptor-selective agonist B-HT 920 uncovered by co-treatment with the D1 agonist SK &F 38393. Psychopharmacology 93:534–537

    Google Scholar 

  • Hsu WH, Schaffer DD, Dyer DC (1986) The emetic effect of B-HT 920 and apomorphine in dogs: antagonism by haloperidol. Life Sci 39:1021–1026

    Google Scholar 

  • Hyttel J (1984) Functional evidence for selective dopamine D1 receptor blockade by SCH 23390. Neuropharmacology 23:1395–1401

    Google Scholar 

  • Iorio LC, Barnett A, Leitz FH, House VP, Korduba CA (1983) SCH-23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J Pharmacol Exp Ther 226:462–468

    Google Scholar 

  • Javitt DC (1987) Negative symptomatology and the PCP (phencyclidine) model of schizophrenia. Hill-side J Clin Psychiatry 9:12–35

    Google Scholar 

  • Kułkarni SK, Arzi A, Kaul PN (1980) Modification of drug induced catatonia and tremors by quipazine in rats and mice. Jpn J Pharmacol 30:129–135

    Google Scholar 

  • Kulkarni SK, Ticku MK (1989) Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK-801 against MES- and picrotoxin-induced convulsions in rats. Life Sci 44:1317–1323

    Google Scholar 

  • Liljequist S, Ossowska K, Grabowska-Anden M, Anden N-E (1991) Effect of the NMDA receptor antagonist, MK-801 on locomotor activity and on the metabolism of dopamine in various brain areas of mice. Eur J Pharmacol 195:55–61

    Google Scholar 

  • Mashurano M, Waddington JL (1986) Stereotyped behaviour in response to the selective D2 receptor agonist RU 24213 is enhanced by pretreatment with the selective D1 agonist SKF 38393. Neuropharmacology 25:947–949

    Google Scholar 

  • Mehta AK, Ticku MK (1990) Role of N-methyl-d-aspartate (NMDA) receptors in experimental catalepsy in rats. Life Sci 46:37–42

    Google Scholar 

  • Meller E, Bordi F, Bohmaker K (1988) Enhancement by the D1 dopamine agonist SKF 38393 of specific components of stereotypy elicited by the D2 agonists LY 171555 and RU 24213. Life Sci 42:2561–2567

    Google Scholar 

  • Mitchell PR, Doggett NS (1980) Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs. Life Sci 26:2073–2081

    Google Scholar 

  • Morelli M, Di Chiara G (1990) MK-801 potentiates dopaminergic D1 but reduces D2 responses in the 6-hydroxydopamine model of Parkinson's disease. Eur J Pharmacol 182:611–612

    Google Scholar 

  • Morpurgo C (1962) Effect of antiparkinsonian drugs on a phenothiazine induced catatonia reaction. Arch Int Pharmacodyn 137:84–90

    Google Scholar 

  • Nielsen EB, Andersen PH (1985) Behavioral evidence that SK&F 38393 is a partial agonist at dopamine receptors. Soc Neurosci Abstr 11:176

    Google Scholar 

  • Pifl C, Hornykiewicz O (1988) Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D1 receptor stimulation. Eur J Pharmacol 146:189–191

    Google Scholar 

  • Roberts PJ, Anderson SD (1979) Stimulatory effect of L-glutamate and related amino acids on3H-dopamine release from rat striatum: an in vitro model for glutamate actions. J Neurochem 32:1539–1545

    Google Scholar 

  • Robertson GS, Robertson HA (1986) Synergistic effects of D1 and D2 dopamine agonists on turning behavior in rats. Brain Res 384:387–390

    Google Scholar 

  • Schmidt WJ, Bubser M (1989) Anticataleptic effects of the N-methyl-d-aspartate antagonist MK-801 in rats. Pharmacol Biochem Behav 32:621–623

    Google Scholar 

  • Schwarcz R, Creese I, Coyle JT, Snyder SH (1978) Dopamine receptors localized on cerebral cortical afferents to rat corpus striatum. Nature 271:766–768

    Google Scholar 

  • Setler PE, Sarau HM, Zircle CL, Saunders HL (1978) The central effects of a novel dopamine agonist. Eur J Pharmacol 50:419–430

    Google Scholar 

  • Snyder SH (1980) Phencyclidine. Nature 285:355–356

    Google Scholar 

  • Spencer NJ (1976) Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester:evidence for glutamic acid as an excitatory transmitter in the rat striatum 102:91–101

  • Stoof JC, Kebabian JW (1981) Opposing roles for D1 and D2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 294:366–368

    Google Scholar 

  • Verma A, Kulkarni SK (1991a) α2-Adrenoceptor- and D2-dopamine receptor-mediated analgesic response of B-HT 920. J Pharm Pharmacol 43:131–133

    Google Scholar 

  • Verma A, Kulkarni SK (1991b) Dopamine receptor mediated hypothermic action of B-HT 920 in rats. J Pharm Pharmacol 43:421–424

    Google Scholar 

  • Verma A, Kulkarni SK (1991c) Chronic electroconvulsive shock alters hypothermic response of B-HT 920 and SKF 38393 in rats. J Pharm Pharmacol 43:813–814

    Google Scholar 

  • Verma A, Kulkarni SK (1991d) Concomitant D1 dopamine receptor activation (SKF 38393) unmasks D2 dopaminergic actions of B-HT 920 in mice. Ind J Exp Biol 29:123–126

    Google Scholar 

  • Verma A, Kulkarni SK (1992) Modulation of MK-801 response by dopaminergic agents in mice. Psychopharmacology 107:431–436

    Google Scholar 

  • Waddington JL, O'Boyle KM (1989) Drug acting on brain dopamine receptors: a conceptual re-evaluation five years after the first selective D-1 antagonist. Pharmacol Ther 43:1–52

    Google Scholar 

  • Wong EHF, Knight AR, Woodruff GN (1988) [3H] MK-801 labels a site on the N-methyl-d-aspartate receptor channel complex in rat brain membranes. J Neurochem 50:274–281

    Google Scholar 

  • Zukin SR, Zukin RS (1979) Specific [3H]-phencyclidine binding in rat central nervous system. Proc Natl Acad Sci USA 76:5372–5376

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacology Division, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India

    Anita Verma & S. K. Kulkarni

Authors
  1. Anita Verma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. K. Kulkarni
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verma, A., Kulkarni, S.K. D1/D2 dopamine and N-methyl-d-aspartate (NMDA) receptor participation in experimental catalepsy in rats. Psychopharmacology 109, 477–483 (1992). https://doi.org/10.1007/BF02247727

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02247727

Key words

Search

Navigation