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Psychopharmacology

, Volume 109, Issue 4, pp 415–421 | Cite as

Differential effects of serotonergic and catecholaminergic drugs on ingestive behavior

  • Karen E. Asin
  • John D. Davis
  • Lisa Bednarz
Original Investigations

Abstract

The serotonergic agonists fenfluramine and fluoxetine and the catecholaminergic agonists amphetamine and phenylpropanolamine are well known to cause a reduction in intake in rats. In the studies reported here we investigated the effects of these drugs on the microstructure of licking behavior of the rat ingesting 0.4 M sucrose. The purpose was to examine the similarities in the behavioral effects within and between these two classes of anorectic agents. The serotonergic agonists fenfluramine and fluoxetine caused a reduction in intake primarily by reducing the size of bursts and clusters of licking within the test meal without affecting the duration of the meal, suggesting a reduction in the palatability of the test solution. The catecholamine agonists amphetamine and phenylpropanolamine reduced intake primarily by reducing the number of bursts and clusters without affecting their size, suggesting a fractionation in the organization of the normal pattern of ingestion. The differences between the two serotonin and the two catecholamine agonists on the microstructure of the licking behavior suggest a different effect of the two neurotransmitters on the motor system that controls ingestive behavior. The similarities between the two different agonists within each class suggests a common neurotransmitter mechanism responsible for these two different effects on the behavior of the animals.

Key words

Anorectics Ingestion rate Microstructure of ingestion Food intake Sugars Carbohydrate Amphetamine Fenfluramine Fluoxetine Phenylpropanolamine Serotonin Norepinephrine 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Karen E. Asin
    • 1
  • John D. Davis
    • 2
  • Lisa Bednarz
    • 1
  1. 1.Abbott Laboratories, Neuroscience Research DivisionPharmaceutical Discovery, Department 47HAbbott ParkUSA
  2. 2.Department of PsychologyUniversity of Illinois, ChicagoChicagoUSA

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