Abstract
The present study was conducted to determine if phenylpropanolamine (PPA) administered during the first week of nicotine termination could reduce or eliminate the body weight rebound which accompanies nicotine cessation. Sprague-Dawley rats were administered nicotine for 2 weeks after which they received either PPA or saline for 1 week. Control animals received saline during both drug periods. Body weight, food consumption, and water consumption were measured daily before drug, during nicotine and PPA administration, and for 14 days after PPA administration. In contrast to animals receiving saline upon termination of nicotine, animals receiving PPA did not gain weight at an accelerated rate. Termination of PPA did not result in a body weight rebound. To the extent that these results generalize to humans, they suggest that PPA could be used to reduce or eliminate postcessation weight gain in smokers who stop smoking.
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References
Averett JW (1962) The effects of nicotine on weight increment, activity, food intake, and water intake in weanling albino rats. Dissertation Abstracts International 23:2187
Becker RF, King JE (1966) Effects of nicotine absorption in rats during pregnancy. Science 154:417–418
Bryson R, Biner OM, McNair E, Bergondy M, Abrams OR (1981) Effects of nicotine on two types of motor activity in rats. Psychopharmacology 73:168–170
Carlson GM, Ruddon RW, Hug CC, Schmiege SK, Bass P (1970) Analysis of the site of nicotine action on gastric antral and duodenal contractile activity. J Pharmacol Exp Ther 172:377–383
Carney RM, Goldberg AP (1984) Weight gain after cessation of cigarette smoking. A possible role for adipose-tissue lipoprotein lipase. N Engl J Med 310:614–616
Emont SL, Cummings KM (1987) Weight gain following cessation: a possible role for nicotine replacement in weight management. Addict Behav 12:151–155
Evans JR, Hughes RE, Jones PR (1967) Some effects of cigarette smoke on guinea-pigs. Proc Nutr Soc 26: xxxvi
Fagerstrom KO (1987) Reducing the weight gain after stopping smoking. Addict Behav 12:91–93
Gritz ER, Ippoliti A, Jarvik ME, Rose JE, Shiffman S, Harrison A, Van Vunakis H (1988) The effect of nicotine on the delay of gastric emptying. Aliment Pharmacol Ther 2:173–178
Gritz ER, Klesges RC, Meyers AW (1989) The smoking and body weight relationship: implications for intervention and postcessation weight control. Ann Behav Med 11:144–153
Gross J, Stitzer ML, Maldonado J (1989) Nicotine replacement: effects on postcessation weight gain. J Consult Clin Psychol 57:87–92
Grunberg NE (1982) The effects of nicotine and cigarette smoking on food consumption and taste preferences. Addict Behav 7:317–331
Grunberg NE, Bowen DJ, Morse DE (1984) Effects of nicotine on body weight and food consumption in rats. Psychopharmacology 83:93–98
Grunberg NE, Bowen DJ, Maycock VA, Nespor SM (1985) The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption. Psychopharmacology 87:198–203
Grunberg NE, Bowen DJ, Winders SE (1986) Effects of nicotine on body weight and food consumption in female rats. Psychopharmacology 90:101–105
Grunberg NE, Winders SE, Popp KA (1987) Sex differences in nicotine's effects on consummatory behavior and body weight in rats. Psychopharmacology 91:221–225
Grunberg NE, Popp KA, Winders SE (1988a) Effects of nicotine on body weight in rats with acess to “junk” foods. Psychopharmacology 94:356–359
Grunberg NE, Popp KA, Bowen DJ, Nespor SM, Winders SE, Eury SE (1988b) Effects of chronic nicotine administration on insulin, glucose, epinephrine, and norepinephrine. Life Sci 42:161–170
Hajek P, Jackson P, Belcher M (1988) Long-term use of nicotine chewing gum. JAMA 260:1593–1596
Hughes RE, Jones PR, Nicholas P (1970) Some effects of experimentally-produced cigarette smoke on growth, vitamin C metabolism and organ weights of guinea-pigs. J Pharm Pharmacol 22:823–827
Klesges RC, Klesges LM (1988) Cigarette smoking as a dieting strategy in a university population. Int J Eating Disord 7:413–419
Klesges RC, Meyers AW, Klesges LM, LaVasque ME (1989) Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature. Psychol Bull 106:204–230
Klesges RC, Klesges LM, Meyers AW, Klem ML, Isbell T (1990) The effects of phenylpropanolamine on dietary intake, physical activity, and body weight after smoking cessation. Clin Pharmacol Ther 47:747–754
Klesges RC, Benowitz NL, Meyers AW (1991) Behavioral and biobehavioral aspects of smoking and smoking cessation: the problem of postcessation weight gain. Behav Ther 22:179–199
McNair E, Bryson R (1983) Effects of nicotine on weight changes and food consummption in rats. Pharmacol Biochem Behav 18:341–344
Morrison CF, Stephenson JA (1972) The occurrence of tolerance to a central depressant effect of nicotine. Br J Pharmacol 46:151–156
Münster G, Bättig K (1975) Nicotine-induced hypophagia and hypodipsia in deprived and in hypothalamically stimulated rats. Psychopharmacologia 41:211–217
Nowack A, Jonderko K, Kaczor R, Nowak S, Skrzypek D (1987) Cigarette smoking delays gastric emptying of a radio-labeled solid food in healthy smokers. Scand J Gastroenterol 22:54–58
Passey RD, Elson LA, Lewis PA (1959) Tobacco smoke and growth rate. British Empire Cancer Campaign, Annual Report 37:89–90
Schechter MD, Cook P (1976) Nicotine-induced weight loss in rats without an effect on appetite. Eur J Pharmacol 38:63–69
US Department of Health and Human Services (1988) The health consequences of smoking: nicotine addiction. A report of the Surgeon General, DHHS Publication No. (CDC) 88-8406. US Government Printing Office, Washington, DC
US Department of Health and Human Services (1989) Reducing the health consequences of smoking: twenty-five years of progress. A report of the Surgeon General, DHHS Publication No. (CDC) 89-8411. US Government Printing Office, Washington, DC
Wellman PJ (1990) A review of the physiological bases of the anorexic action of phenylpropanolamine (d,l-norephedrine). Neurosci Biobehav Rev 14:339–355
Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T (1991) Smoking cessation and severity of weight gain in a national cohort. N Engl J Med 324[11]:739–745
Winders SE, Grunberg NE (1989) Nicotine, tobacco smoke, and body weight: a review of the animal literature. Ann Behav Med 11:125–133
Winders SE, Grunberg NE (1990) Effects of nicotine on body weight, food consumption and body composition in male rats. Life Sci 46:1523–1530
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Support for this study was received from a Centers of Excellence grant awarded to the Department of Psychology, Memphis State University, by the state of Tennessee. This study also received support from National Heart, Lung, and Blood Institute grant no. HL-39332.
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Winders, S.E., Dykstra, T., Coday, M.C. et al. Use of phenylpropanolamine to reduce nicotine cessation induced weight gain in rats. Psychopharmacology 108, 501–506 (1992). https://doi.org/10.1007/BF02247428
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DOI: https://doi.org/10.1007/BF02247428