The possibility that a sub-clinical deficiency of the trace element selenium might exist in a sample of the British population was examined by giving a selenium supplemeted for 5 weeks. Using a double-blind crossover design 50 subjects received either a placebo or 100 µg selenium on a daily basis. On three occasions they filled in the Profile of Moods state. Mood did not change when taking the placebo, whereas when taking the selenium the subjects reported a substantial improvement after both 2.5 and 5 weeks.
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Benton, D., Cook, R. Selenium supplementation improves mood in a double-blind crossover trial. Psychopharmacology 102, 549–550 (1990). https://doi.org/10.1007/BF02247139