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Psychopharmacology

, Volume 102, Issue 4, pp 535–543 | Cite as

Comparison of the effects of Alzheimer's disease, normal aging and scopolamine on human transient visual evoked potentials

  • A. T. Smith
  • F. Early
  • G. H. Jones
Original Investigations

Abstract

Transient visual evoked potentials elicited by the onset of a patterned stimulus were recorded in patients suffering from Alzheimer's disease (AD), in healthy elderly controls and in healthy young individual. The latencies and amplitudes of both the components studied were adversely affected by normal aging and one of the components, CI, but not the other, CII, showed further deterioration in AD. These changes occurred over a range of stimulus contrast levels. The changes found in AD, but not those seen in normal aging, could be mimicked by administration of the cholinergic antagonist scopolamine to young volunteers.

Key words

Alzheimer's disease Aging Scopolamine Transient visual evoked potentials 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • A. T. Smith
    • 1
  • F. Early
    • 1
  • G. H. Jones
    • 2
  1. 1.School of PsychologyUniversity of Wales College of CardiffCardiffWales, UK
  2. 2.Department of Psychological MedicineUniversity of Wales College of Medicine, Whitchurch HospitalCardiffWales, UK

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