Comparison of the effects of Alzheimer's disease, normal aging and scopolamine on human transient visual evoked potentials
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Transient visual evoked potentials elicited by the onset of a patterned stimulus were recorded in patients suffering from Alzheimer's disease (AD), in healthy elderly controls and in healthy young individual. The latencies and amplitudes of both the components studied were adversely affected by normal aging and one of the components, CI, but not the other, CII, showed further deterioration in AD. These changes occurred over a range of stimulus contrast levels. The changes found in AD, but not those seen in normal aging, could be mimicked by administration of the cholinergic antagonist scopolamine to young volunteers.
Key wordsAlzheimer's disease Aging Scopolamine Transient visual evoked potentials
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- Cosi V, Gozzoli VI, Corona A, Geroni M, Callieco R (1982) Visual evoked potentials in aging of the brain. In: Courjon J, Mauguiere F, Revol M (eds) Clinical applications of evoked potentials in neurology. Raven Press, New York, pp 109–115Google Scholar
- Flicker C, Serby M, Ferris SH (1990) Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed. Psychopharmacology 100:243–250Google Scholar
- Mesulam MM, Mufson EJ, Levey AI, Wainer BH (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkey. J Comp Neurol 214:170–197CrossRefPubMedGoogle Scholar
- Morrison JD, McGrath C (1985) Assessment of the optical contributions to the age-related deterioration in vision. Q J Exp Psychol 70:249–269Google Scholar
- Rossor MN, Iversen LL, Reynolds GP, Mountjoy CQ, Roth M (1984) Neurochemical characteristics of early and late onset types of Alzheimer's disease. Br Med J 288:961–964Google Scholar
- Sims NR, Bowen DM, Davison AN (1982) Acetylcholine synthesis and glucose metabolism in aging and dementia. In: Giacobini E, Filogamo G, Vernadakis A (eds) The aging brain: cellular and molecular mechanisms of aging in the nervous system. Raven Press, New YorkGoogle Scholar
- Sitaram N, Weingartner H, Gillin JC (1978) Human serial learning: enhancement with arecholine and choline and impairment with scopolamine. Science 201:274–276Google Scholar
- Sloane ME, Owsley C, Jackson CA (1988) Aging and luminanceadaptation effects on spatial contrast sensitivity. J Opt Soc Am A5:2181–2190Google Scholar
- Visser SL, Stam FC, Tilburg van W, Velde op den W, Blom JL, Rijke de W (1976) Visual evoked potentials in senile dementia (Alzheimer type) and in non-organic behavioural disorders in the elderly: comparison with EEG parameters. Electroencephalogr Clin Neurophysiol 40:385–392CrossRefPubMedGoogle Scholar
- Wesnes K, Warburton DM (1978) In: Thornton RE (ed) Smoking behaviour: physiologica and psychological influences. Churchill Livingstone, Edinburgh, pp 131–147Google Scholar