, Volume 102, Issue 4, pp 529–534 | Cite as

Lateral striatal cholinergic mechanisms involved in oral motor activities in the rat

  • J. D. Salamone
  • C. J. Johnson
  • L. D. McCullough
  • R. E. Steinpreis
Original Investigations


These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0–8.0 mg/kg pilocarpine increased chewing movements and tongue protrusions. In the second experiment, chronic guide cannulae were implanted bilaterally in ventromedial or ventrolateral striatum, and rats were injected with saline, 30, and 60 µg pilocarpine (per side). A dose-related increase in vaculous chewing was induced by injections of pilocarpine in the ventrolateral but not the ventromedial striatum. Tongue protrusions were induced by injections of pilocarpine into the ventromedial and the ventrolateral striatum. A third experiment demonstrated that this response was blocked completely by 10 µg scopolamine co-administered via the same cannulae, but the response was not reduced significantly by 10 µg haloperidol. These results indicate that ventrolateral striatal cholinergic mechanisms are involved in oral motor activities in the rat. This syndrome may provide a model for human clinical phenomena such as parkinsonian tremor.

Key words

Pilocarpine Muscarinic receptors Chewing Movement Parkinonism 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. D. Salamone
    • 1
  • C. J. Johnson
    • 1
  • L. D. McCullough
    • 1
  • R. E. Steinpreis
    • 1
  1. 1.Department of PsychologyUniversity of ConnecticutStorrsUSA

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