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Effects of neuroleptics on electrodermal activity in schizophrenic patients: a review

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Abstract

The effects of neuroleptics on electrodermal activity (EDA) in schizophrenic patients are addressed in a review of research conducted since the publication of an earlier review by Tecce and Cole in 1972. It is concluded that neuroleptics reduce skin conductance level but that effects on other electrodermal parameters are less robust and may be confounded by methodological issues. A discussion of these issues is presented and directions for future research are proposed.

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References

  • Bartfai A, Edman G, Lavender SE, Schalling D, Sedvall G (1984) Bilateral skin conductance activity, clinical symptoms and CSF monoamine metabolite levels in unmedicated schizophrenics, differing in rate of habituation. Biol Psychol 18:201–218

    PubMed  Google Scholar 

  • Bernstein AS (1967) The orienting reflex as a research tool in the study of psychotic populations. In: Ruttkay-Nedecky I, Ciganels Y, Zikmund V, Kellerova V (eds) Mechanisms of the orienting reaction in man. Publishing House of the Slovak Academy of Sciences, Bratislava, Czekoslovakia, pp 257–266

    Google Scholar 

  • Bernstein AS (1970) The phasic electrodermal orienting response in chronic schizophrenics: response to auditory signals of varying intensity. J Abnorm Psychol 16:263–273

    Google Scholar 

  • Bernstein AS (1987) Orienting response research in schizophrenia: where we have come and where we might go. Schizophr Bull 13:623–641

    PubMed  Google Scholar 

  • Bernstein AS, Taylor KW (1979) The interaction of stimulus information and potential stimulus significance in eliciting the skin conductance orienting response. In: Kimmel H, Van Olste E, Orlebeke, J. The oreinting reflex in humans. Erlbaum, Hillsdale, New Jersey, pp 499–519

    Google Scholar 

  • Bernstein AS, Taylor KW, Starkey P, Juni S, Lubowsksy J, Paley H (1981) Bilateral skin conductance, finger pulse volume, and EEG orienting response to tones of differing intensities in chronic schizophrenics and controls. J Nerv Ment Dis 169:513–528

    PubMed  Google Scholar 

  • Bernstein AS, Frith CD, Gruzelier JH, Patterson T, Venables PH, Straube E (1982) An analysis of skin conductance orienting response in samples of American, British, and German schizophrenics. Biol Psychol 14:155–211

    Article  PubMed  Google Scholar 

  • Bernstein AS, Reidel JA, Pava J, Schnur DB, Lubowsky J (1985a) A limiting factor in the normalization of schizophrenic orienting response dysfunction. Schizophr Bull 11:230–254

    PubMed  Google Scholar 

  • Bernstein AS, Taylor KW, Weinstein E, Reidel J (1985b) The effect of stimulus significance on relatively sustained (tonic-like) and relatively transient (phasic-like) aspects of electrodermal, eye-blink, and heart rate response. Biol Psychol 21:183–228

    Article  PubMed  Google Scholar 

  • Bernstein AS, Reidel JA, Graae F, Seidman D, Steele H, Connolly J, Lubowski J (1988) Schizophrenia is associated with altered orienting activity, depression with electrodermal (cholinergic) deficit and normal orienting response. J Abnorm Psychol 97:3–12

    Article  PubMed  Google Scholar 

  • Cannon T, Mednick SA, Parnas J (1990) Two pathways to schizophrenia in children at risk. In: Rubens L, Rutter M (eds) Straight and devious pathways from childhood to Adulthood, Cambridge University Press, Cambridge 328–350

    Google Scholar 

  • Dawson M, Nuechterlein K (1984) Electrodermal and other psychophysiological dysfunctions in the developmental course of schizophrenic disorders. Schizophr Bull 10:204–232

    PubMed  Google Scholar 

  • Erlenmeyer-Kimling L, Freidman D, Cornblatt B, Jacobson R (1985) Electrodermal recovery data on children of schizophrenic parents. Psychiatry Res 14:149–161

    Article  PubMed  Google Scholar 

  • Fowles DC (1986) The eccrine system and electrodermal activity. In: Coles MGH, Donchin E, Porges SW (eds) Psychophysiology, systems, processes, and applications. The Guilford Press, New York, London, pp 508–610

    Google Scholar 

  • Frith CD, Stevens M, Johnstone EC, Crow TJ (1979) Skin conductance responsivity during acute episodes of schizophrenia as a predictor of symptomatic improvement. Psychol Med 9:101–106

    PubMed  Google Scholar 

  • Frith C, Stevens M, Johnstone E, Crow T (1982) Skin conductance habituation during acute episodes of schizophrenia: qualitative differences from anxious and depressed patients. Psychol Med 12:575–583

    PubMed  Google Scholar 

  • Frith C, Stevens M, Johnstone E, Crow T (1988) Acute schizophrenic patients fail to modulate there level of attention. J Psychophysiol 2:195–200

    Google Scholar 

  • Gjerde PF (1983) Attentional capacity dysfunction and arousal in schizophrenia. Psychol Bull 93:57–72

    Article  PubMed  Google Scholar 

  • Green MF, Nuechterlein KH (1988) Neuroleptic effects on electrodermal responsivity to soft tones and loud noise in schizophrenia. Psychiatry Res 24:79–86

    Article  PubMed  Google Scholar 

  • Green MF, Nuechterlein KH, Satz P (1987) Electrodermal activity and symptomatology in schizophrenia. In: Harvey PD, Walker EE (eds) Positive and negative symptoms in psychosis: description, research, and future directions. Lawrence Erlbaum, Hillsdale, New Jersey, London, pp 243–257

    Google Scholar 

  • Green MF, Nuechterlein K, Satz P (1989) The relationship of symptomatology and medication to electrodermal activity in schizophrenia. Psychophysiology 26:148–157

    PubMed  Google Scholar 

  • Gruzelier JH (1976) Clinical attributes of schizophrenic skin conductance responders and non-responders. Psychol Med 6:245–249

    PubMed  Google Scholar 

  • Gruzelier JH, Hammond NV (1978) The effect of chlorpromazine upon psychophysiological, endocrine, and information processing measures in schizophrenia. J Psychiatr Res 14:167–182

    Article  PubMed  Google Scholar 

  • Gruzelier JH, Venables P (1972) Skin conductance orienting response in a heterogeneous sample of schizophrenics: possible evidence for limbic dysfunction. J Nerv Ment Dis 155:277–287

    PubMed  Google Scholar 

  • Gruzelier JH, Venables P (1975) Relations between two flash discrimination and electrodermal activity reexamined in schizophrenics and normals. J Psychiatr Res 12:73–85

    Article  PubMed  Google Scholar 

  • Kornetsky C, Mirsky AF (1966) On certain psychopharmacological and physiological differences between schizophrenic and normal persons. Psychopharmacologia 8:309–318

    Article  PubMed  Google Scholar 

  • Kornetsky C, Orzack MH (1978) Physiologic and behavioral correlates of attention dysfunction in schizophrenic patients. In: Wynne LC, Cromwell R, Matthyesse S (eds) The nature of schizophrenia: new approaches to research and treatment. Wiley, New York, Chichester Brisbane Toronto, pp 196–204

    Google Scholar 

  • Lacey JI (1967) Somatic response patterning and stress: some revisions of activation theory. In: Appley MH, Trumbull R (eds) Psychological issues in research. Appleton-Century-Crofts, New York, pp 14–44

    Google Scholar 

  • Larsen PB, Schneiderman N, Decarlo Pasin R (1986) Physiological basis of cardiovascular physiology. In: Coles MGH, Donchin E, Porges SW (eds) Psychophysiology, systems, processes, and applications. Guilford Press, New York London, pp 122–165

    Google Scholar 

  • Levinson DF, Edleberg R (1985) Scoring criteria for response latency and habituation in electrodermal research: a critique. Psychophysiology 22:417–426

    PubMed  Google Scholar 

  • Levinson DF, Edleberg R, Maricq H (1985) The skin conductance orienting response in neuroleptic free schizophrenics: replication of scoring the criteria effect Biol Psychiatry 20:646–653

    PubMed  Google Scholar 

  • Magaro P (1973) Skin conductance basal level and reactivity in schizophrenia as a function of chronicity, premorbid adjustment, diagnosis and medication. J Abnorm Psychol 81:270–281

    PubMed  Google Scholar 

  • McGuiness D, Pribram K (1980) The neuropsychology of attention: emotional and motivational controls. In: Mc Wittrock (ed) The brain and psychology. Academic Press, New York, pp 95–139

    Google Scholar 

  • Ohman A (1979) The orienting response, attention and learning: an information processing perspective. In Kimmel H, Van Olste E, Orlebeke J (eds) The orienting reflex in humans. Erlbaum, Hillsdale, New Jersey, pp 443–471

    Google Scholar 

  • Ohman A (1981) Electrodermal activity and vulnerability to schizophrenia: a review. Biol Psychol 12:87–145

    PubMed  Google Scholar 

  • Ohman A, Nordby H, D'Elia G (1989) Orienting in schizophrenia: habituation to auditory stimuli of constant and varying intensity. Psychophysiology 26:48–62

    PubMed  Google Scholar 

  • Orzack MH, Kornetsky K (1966) Attention dysfunction in chronic schizophrenia. Arch Gen Psychiatry 14:323–326

    PubMed  Google Scholar 

  • Richelson E (1984) Neuroleptic affinities for human brain receptors and their sue in predicting adverse effects. J Clin Psychiatry 45:331–336

    PubMed  Google Scholar 

  • Rubens R, Lapidus LB (1978) Schizophrenic patterns of arousal and stimulus barrier functioning. J Abnormal Psychol 87:199–200

    Article  Google Scholar 

  • Shields SA, Macdowell KA, Fairchild SB, Campbell ML (1987) Is mediation of sweating cholinergic, adrenergic or both? A comment on the literature. Psychophysiology 24:312–318

    PubMed  Google Scholar 

  • Siddle D, Stephenson P, Spinks JA (1983) Elicitation and habituation of the orienting response. In: Siddle D (ed) Orienting and habituation: perspectives in human research. Wiley, New York, pp 476–504

    Google Scholar 

  • Sokolov E (1963) Perception and the conditioned reflex. Pergamon Press, New York

    Google Scholar 

  • Spohn HE, Fitzpatrick T (1980) Informed consent bias in samples of schizophrenic subjects at risk for drug withdrawal. J Abnorm Psychol 89:79–92

    PubMed  Google Scholar 

  • Spohn HE, Lacoursiere RB, Thompson K, Coyne L (1977) Phenothiazine effects on psychological and physiological dysfunction in chronic schizophrenics. Arch Gen Psychiatry 34:633–644

    PubMed  Google Scholar 

  • Spohn HE, Coyne L, Lacoursiere R, Mazur D, Hayes K (1985) Relation of neuroleptic dose and tardive dyskinesia to attention, information processing, and psychophysiology in medicated schizophrenics. Arch Gen Psychiatry 42:849–859

    PubMed  Google Scholar 

  • Spohn HE, Coyne L, Wilson JK, Hayes K (1989) Skin-conductance orienting response in chronic schizophrenics: the role of neuroleptics. J Abnorm Psychol 98:478–486

    Article  PubMed  Google Scholar 

  • Straube E (1979) On the meaning of electrodermal nonresponding in schizophrenia. J Nerv Ment Dis 167:601–611

    PubMed  Google Scholar 

  • Straube ER, Scheid HW, Rein W, Beyer-Pfaff U (1987) Autonomic nervous system differences as predictors of short-term outcome in schizophrenics. Pharmacopsychiatry 20:105–110

    PubMed  Google Scholar 

  • Tecce JJ, Cole JO (1972) Psychophysiologic responses of schizophrenics to drugs. Psychopharmacologia 24:159–200

    Article  PubMed  Google Scholar 

  • Venables PH, Bernstein AS (1983) The orienting response and psychopathology: schizophrenia. In: Siddle D (ed) Orienting and habituation: perspectives in human research. Wiley, New York, pp 476–504

    Google Scholar 

  • Yamitsi S, Laikos A, Papakostas Y (1987) Electrodermal responding and chlorpromazine treatment in schizophrenia. Br J Psychiatry 150:850–853

    PubMed  Google Scholar 

  • Zahn TP (1986) Psychophysiologic approaches to psychopathology. In: Coles MGH, Donchin E, Porges SW (eds) Psychophysiology, systems, processes, and applications. Guilford Press, New York London, pp 508–610

    Google Scholar 

  • Zahn TP, Rosenthal D, Lawlor WG (1968) Electrodermal and heart rate orienting in chronic schizophrenia. J Psychiatr Res 6:117–134

    Article  PubMed  Google Scholar 

  • Zahn TP, Carpenter WT, McGlashan TH (1981) Autonomic nervous system in acute schizophrenia II: relationships to short term prognosis and clinical state. Arch Gen Psychiatry 38:260–266

    PubMed  Google Scholar 

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Authors and Affiliations

  1. the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA

    David B. Schnur

  2. Department of Clinical Neuropsychiatry, New York State Psychiatric Institute, 722 West 168 Street, Box 72, 10032, New York, NY, USA

    David B. Schnur

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  1. David B. Schnur
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Schnur, D.B. Effects of neuroleptics on electrodermal activity in schizophrenic patients: a review. Psychopharmacology 102, 429–437 (1990). https://doi.org/10.1007/BF02247121

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  • DOI: https://doi.org/10.1007/BF02247121

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