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Bombesin-induced anorexia requires central bombesin receptor activation: independence from interaction with central catecholaminergic systems

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Abstract

Intraperitoneal (IP) administration of bombesin (BBS; 2.5–20 µg/kg) induced a dose-dependent inhibition of food intake. The effect was decreased by intraventricular (ICV) administration of bombesin receptor antagonist [Leu14-ψ (CH2 NH)-Leu13] (3 µg/rat) but not by the D1 antagonist SCH 23390, the D2 antagonists sulpiride and pimozide, the dopamine antagonist cis-flupentixol, adrenoceptor blockers phenoxybenzamine or propranolol and serotonergic antagonist methergoline. It is concluded that BBS-induced suppression of feeding may be mediated through central BBS receptors, and is independent of interaction with brain catecholaminergic system.

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Authors and Affiliations

  1. Department of Physiology, Medical Faculty, Shahid Beheshti University of Medical Sciences, Iran

    F. Motamedi

  2. Department of Physiology, College of Medical Science, University of Tarbiat Modarress, Iran

    A. Rashidy-Pour & M. Badavi

  3. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran

    M. R. Zarrindast

Authors
  1. F. Motamedi
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  2. A. Rashidy-Pour
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  3. M. R. Zarrindast
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  4. M. Badavi
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Motamedi, F., Rashidy-Pour, A., Zarrindast, M.R. et al. Bombesin-induced anorexia requires central bombesin receptor activation: independence from interaction with central catecholaminergic systems. Psychopharmacology 110, 193–197 (1993). https://doi.org/10.1007/BF02246972

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  • DOI: https://doi.org/10.1007/BF02246972

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