Abstract
Intraperitoneal (IP) injection of high doses of theophylline decreased memory acquisition dose dependently. Low but not high doses of the dopamine receptor D2 antagonist sulpiride and the dopamine D1 receptor antagonist SCH 23390 decreased the theophylline response. Pimozide and the β-adrenoreceptor propranolol also decreased the drug response. The antimuscarinic agent atropine, the α-adrenoceptor phenoxybenamine and the 5-HT antagonist metergoline did not affect the response induced by theophylline. It is concluded that dopamine and β-adrenergic receptor mechanisms may be involved in the theophyllineinduced attenuation of memory acquisition.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berkowitz BA, Tarver JH, Spector S (1970) Release of norepinephrine in the central nervous system by theophylline and caffeine. Eur J Pharmacol 10:64–71
Bracs PU, Gregory P, Jackson DM (1984) Passive avoidance in rats: disruption by dopamine applied to the nucleus accumbens. Psychopharmacology 83:70–75
Casas M, Ferre S, Cobos A, Grau JM, Jane F (1989) Relationship between rotational behavior induced by apomorphine and caffeine in rats with unilateral lesions of the nigrostriatal pathway. Neuropharmacology 28:407–409
Choi OH, Shamin MT, Padget WL, Daly JW (1988) Caffeine and theophylline analogues: correlation of behavioural effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life Sci 43:387–398
Christensen AV, Arnt J, Hyttel J, Svedsen O (1984) Behavioral correlates to dopamine D1 and D2 antagonists. Pol J Pharmacol 36:249–264
Corrodi H, Fuxe K, Jonson G (1972) Effect of caffeine on central monoamine neurons. J Pharm Pharmacol 24:155–158
Daly JW (1982) Adenosine receptors: targets for future drugs. J Med Chem 25:197–207
Di Chiara G, Porceddu ML, Vargiu L, Argiolas A, Gessa GL (1976) Evidence for dopamine receptors mediating sedation in mouse brain. Nature 264:564–567
Gerber JG, Nies AS (1985) β-Adrenergic blocking drugs. Annu Rev Med 36:145–164
Gozzani JL, Izquierdo I (1976) Possible peripheral adrenergic and central dopaminergic influences in memory consolidation. Psychopharmacology 49:109–111
Herrera-Marschitz M, Casas M, Ungerstedt U (1988) Caffeine produces contralateral rotations in rats with unilateral dopamine denervation: comparisons with apomorphine-induced responses. Psychopharmacology 94:38–45
Hyttel J (1984) Functional evidence for selective dopamine D1 receptor blockade by SCH 23390. Neuropharmacology 23:1395–1401
Lin T, Chandra A, Liu GG (1980) The effect of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperature. J Pharm Pharmacol 21:204–208
Majerus PW, Broze GJ, Jr, Miletich JP, Tollefsen DM (1991) Anticoagulant, thrombolytic and antiplatelet drug. In: Goodman and Gilman's the pharmacological basis of therapeutics, 8th edn. Goodman Gilman A, Rall Tw, Nies AS, Taylor P, Pergamon Press, New York pp 1311–1331
Mally J (1988) Effect of low dose theophylline therapy on essential tremor. New Trends Clin Neuropharmacol 1:51–55
Mally J (1989) Aminophylline and essential tremor. Lancet 2:278–279
Morley MJ, Bradshow CM, Szabadi E (1987) Attenuation by pimozide of the suppressant effect ofd-amphetamine on operant behaviour. Psychopharmacology 91:239–243
Quartermain D, Judge ME, Leo P (1988) Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems. Pharmacol Biochem Behav 30:77–81
Rall TW (1985) Central nervous system stimulants. In: Goodman AG et al. (eds), The pharmacological basis of Therapeutics. Macmillan, New York, pp 589–603
Stoof JC, Kebabian JW (1984) Two dopamine receptors; biochemistry, physiology and pharmacology. Life Sci 35:2281–2296
Waldeck B (1971) Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain. J Pharm Pharmacol 23:824–830
Watanabe H, Uramoto H (1986) Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors. Neuropharmacology 25:577–581
Zarrindast MR, Moghadampour E (1989) Opposing influences of D1 and D2 dopamine receptor activation on morphine-induced antinociception. Arch Int Pharmacol 300:37–50
Zarrindast MR, Nasir T (1991) Methylxanthine-induced attenuation of pecking in chickens. Br J Pharmacol 104:327–330
Zarrindast MR, Nikfar Sh (1994) Different influences of adenosine receptor agonist and antagonist on morphine antinociception in mice. Gen Pharmacol 25:139–142
Zarrindast MR, Poursoltan M (1989) Interactions of drugs acting on central dopamine receptors and cholinoceptors on yawning responses in the rat induced by apomorphine, bromocriptine or physostigmine. Br J Pharmacol 96:843–848
Zarrindast MR, Shafaghi B (1994) Effects of adenosine agoinst and antagonists on acquisition of passive avoidance learning. Eur J Pharmacol 256:233–239
Zarrindast MR, Satari-Naeini M, Motamedi F (1992) Effect of D-1 or D-2 receptor stimulation on memory retrieval in mice. J Psychopharmacol 6:526–531
Zarrindast MR, Sabetkasai M, Khakpour Sh (1993) Effects of drugs active at adenosine receptors on stress induced analgesia in mice. Arch Int Pharmacodyn 325:51–60
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zarrindast, M.R., Shafaghi, B. & Jamali-Raeufy, N. Effects of high doses of theophylline on memory acquisition. Psychopharmacology 122, 307–311 (1995). https://doi.org/10.1007/BF02246553
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02246553